KIAA0141 Rabbit Polyclonal Antibody

CAT#: TA326627

Rabbit Polyclonal DELE Antibody

Product Images

Western blot analysis of DELE in rat brain tissue lysate with DELE antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

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  Immunofluorescence of DELE in human brain tissue with DELE antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DELE antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DELE.
• Formulation: DELE Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: DELE Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: KIAA0141
• Database Link:
  NP_055588
  Entrez Gene 307480 RatEntrez Gene 9812 Human
  UniProt ID Q14154
• Background: DELE Antibody: DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-α and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-α, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.
• Synonyms: DELE