RAGE (AGER) Rabbit Polyclonal Antibody

CAT#: TA327041

Rabbit anti-AGER Polyclonal Antibody

Product Images

Western blot analysis of extracts of mouse lung cell line, using AGER antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human AGER
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: advanced glycosylation end product-specific receptor
• Database Link:
  NP_001127
  Entrez Gene 11596 MouseEntrez Gene 81722 RatEntrez Gene 177 Human
  UniProt ID Q15109
• Background: The receptor for advanced glycation end products (RAGE) is member of the immunoglobulin (Ig) superfamily. It can be expressed as full-length, membrane-bound RAGE isoform 1 or as a secreted sRAGE protein that lacks a transmembrane domain. RAGE is detected during early developmental stages and in the lung under normal physiological conditions and is upregulated at sites of inflammation. Advanced glycation end products (AGEs) and a variety of other ligands interact with this receptor. Ligand binding activates full-length RAGE and initiates downstream signaling pathways that include activation of NF-¦ÊB, which leads to production of pro-inflammatory cytokines and inflammation. Activation of these pathways has been implicated in various disease states including Alzheimer disease, diabetes, arthritis, and atherosclerosis. Soluble RAGE can competitively bind RAGE ligands in the extracellular environment, which prevents ligand interaction with full-length RAGE at the cell surface.
• Synonyms: RAGE

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane