Gastrin (GAST) Rabbit Polyclonal Antibody

CAT#: TA327679

Rabbit Polyclonal Gastrin Antibody

Product Images

Immunohistochemistry staining of Paraffin Stomach tissue by Gastrin antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 1:100 - 1:500
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Formulation: This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: gastrin
• Database Link:
  NP_000796
  Entrez Gene 2520 Human
  UniProt ID P01350
• Synonyms: GAS
• Note: Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms: G34 and G17. They activate two different receptors: the CCK-1 receptor, which has low affinity for gastrin but high affinity for the related hormone cholecystokinin (CCK), and the CCK-2 receptor, which has high affinity for both gastrin and CCK and mediates the acid-secretory as well as the proliferative effects of gastrin. More recently, gastrin has been suggested to induce leukocyte-endothelial cell interactions and to have a pro-inflammatory effect.Anti-gastrin stains G-cells of human antral/pyloric mucosa and cells producing gastrin or a structural gastrin analog as is seen in stomach; no staining of other cells or tissue types has been observed. This antibody may react with sulfated and non-sulfated forms of gastrin.

Reference Data

• Protein Families: Druggable Genome, Secreted Protein