STAT2 Rabbit Polyclonal Antibody [Clone ID: Poly6245]

CAT#: TA328010

Rabbit Polyclonal anti-STAT2 Antibody

Product Images

Hela cell extract was resolved by electrophoresis, transferred to nitrocellulose, and probed with rabbit anti-STAT2 polyclonal antibody. Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence system.

Specifications

Product Data

• Clone Name: Poly6245
• Applications: WB
• Recommended Dilution: WB, IP
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide mapping to the carboxy terminus of human STAT2
• Formulation: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% gelatin.
• Purification: The antibody was purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 113 kD
• Gene Name: signal transducer and activator of transcription 2
• Database Link:
  NP_005410
  Entrez Gene 6773 Human
  UniProt ID P52630
• Background: STAT2, a 113 kD member of the STAT (signal transducer and activators of transcription) protein family, is phosphorylated in response to interferon alpha receptor signaling by Janus kinase I. Phosphorylation of STAT 2 induces nuclear translocation to activate transcription. STAT2 is highly expressed in the skin and thymus. STAT 2 forms complex with STAT1 and p48 to activate transcription and does not bind DNA directly. STAT 3 interacts with interferon regulatory factor 9, interferon alpha receptor, STAT 1, p48, and CREB binding protein. The Poly6245 antibody recognizes the C-terminal region of human STAT2 and has been shown to be useful for Western blotting, immunoprecipitation, and immunohistochemistry.
• Synonyms: IMD44; ISGF-3; P113; STAT113

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Chemokine signaling pathway, Jak-STAT signaling pathway