DOK4 Rabbit Polyclonal Antibody

CAT#: TA332374

Rabbit anti-DOK4 Polyclonal Antibody

Product Images

Western blot analysis of extracts of MCF7 cells, using DOK4 antibody.

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  Immunohistochemistry of paraffin-embedded Prostate cancer using DOK4 Antibody.

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  Immunohistochemistry of paraffin-embedded human stomach cancer using DOK4 antibody at dilution of 1:200 (200x lens).

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  Immunohistochemistry of paraffin-embedded mouse kidney using DOK4 antibody at dilution of 1:200 (200x lens).

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  Immunofluorescence analysis of HeLa cell using DOK4 antibody. Blue: DAPI for nuclear staining.

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Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200;IF 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant Protein of human DOK4
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 326
• Gene Name: docking protein 4
• Database Link:
  NP_060580
  Entrez Gene 114255 MouseEntrez Gene 361364 RatEntrez Gene 55715 Human
  UniProt ID Q8TEW6
• Background: The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.
• Synonyms: IRS-5; IRS5

Reference Data

• Protein Families: Druggable Genome