HTRA2 Rabbit Polyclonal Antibody

CAT#: TA332894

Rabbit anti-HTRA2 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using HTRA2 antibody.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human HTRA2
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 458
• Gene Name: HtrA serine peptidase 2
• Database Link:
  NP_659540
  Entrez Gene 64704 MouseEntrez Gene 297376 RatEntrez Gene 27429 Human
  UniProt ID O43464
• Background: This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
• Synonyms: OMI; PARK13; PRSS25

Reference Data

• Protein Families: Druggable Genome, Protease, Transmembrane
• Protein Pathways: Parkinson's disease