TrkB (NTRK2) Rabbit Polyclonal Antibody

CAT#: TA333267

Phospho-NTRK2-Y515 Rabbit Polyclonal Antibody

Product Images

Immunofluorescence staining of methanol-fixed Hela cells, using Phospho-NTRK2-Y515 antibody.

Specifications

Product Data

• Applications: IF
• Recommended Dilution: IF 1:100-1:200
• Reactivities: Human
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A phospho specific peptide corresponding to residues surrounding Y515 of human NTRK2 (NP_001018074.1)
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: neurotrophic receptor tyrosine kinase 2
• Database Link:
  NP_001007098
  Entrez Gene 18212 MouseEntrez Gene 25054 RatEntrez Gene 4915 Human
  UniProt ID Q16620
• Background: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.
• Synonyms: GP145-TrkB; trk-B; TRKB

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: MAPK signaling pathway, Neurotrophin signaling pathway