GATA4 Mouse Monoclonal Antibody [Clone ID: 6H10]

CAT#: TA336777

Mouse Monoclonal GATA-4 Antibody (6H10)

Product Images

Western Blot: GATA4 Antibody (6H10) TA336777 - Western blot analysis using anti-GATA4 mAb against rat fetal heart (1) and adult heart (2) tissues lysate.

Specifications

Product Data

• Clone Name: 6H10
• Applications: WB
• Recommended Dilution: Western Blot: 1:500-1:2000, ELISA: 1:10000
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of human GATA4 expressed in E. coli. [UniProt# P43694]
• Formulation: Preservative: 0.05% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Ascites
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 46 kDa
• Gene Name: GATA binding protein 4
• Database Link:
  NP_002043
  Entrez Gene 14463 MouseEntrez Gene 54254 RatEntrez Gene 2626 Human
  UniProt ID P43694
• Background: GATA4, also known as GATA binding protein 4, is a 46 kDa member of the GATA family of zinc-finger transcription factors. Members of this family is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. These factors recognize the GATA motif which is present in the promoters of many genes. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.
• Synonyms: ASD2; TACHD; TOF; VSD1
• Note: This GATA4 (6H10) antibody is useful for Western blot and ELISA.

Reference Data

• Protein Families: Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors