Endothelin 3 (EDN3) Rabbit Polyclonal Antibody

CAT#: TA343125

Rabbit Polyclonal Anti-EDN3 Antibody

Product Images

WB Suggested Anti-EDN3 Antibody; Titration: 1.0 ug/ml; Positive Control: Fetal Kidney

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-EDN3 antibody: synthetic peptide directed towards the C terminal of human EDN3. Synthetic peptide located within the following region: LHFCTQTLDVSSNSRTAEKTDKEEEGKVRGANRGLCQRRLKSRTNKASRL
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 24 kDa
• Gene Name: endothelin 3
• Database Link:
  NP_996915
  Entrez Gene 1908 Human
  UniProt ID P14138
• Background: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
• Synonyms: ET-3; ET3; HSCR4; PPET3; WS4B
• Note: Immunogen Sequence Homology: Human: 100%; Pig: 85%

Reference Data

• Protein Families: Druggable Genome, Secreted Protein