MBD3 Rabbit Polyclonal Antibody

CAT#: TA347553

Rabbit Polyclonal Anti-MBD3 Antibody

Product Images

Western blot analysis on Jurkat cell lysate using MBD3 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-MBD3 Antibody: A synthesized peptide derived from human MBD3
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 33 kDa
• Gene Name: methyl-CpG binding domain protein 3
• Database Link:
  NP_001268382
  Entrez Gene 17192 MouseEntrez Gene 53615 Human
  UniProt ID O95983
• Background: MBD3 methyl-CpG binding (MBD) proteins appear to bind differentially methylated domains (DMDs) of DNA, to recruit repression complexes, and to silence the locus. The methyl CpG binding domain of human MBD3 may not directly bind mCpG but does interact with the NuRD/Mi2 components HDAC1 and MTA2. Plays a role in histone deacetylation and nucleosome remodeling. Increased levels have been reported in lung cancer and glioblastomas and may be a therapeutic target.
• Synonyms: MBD3
• Note: MBD3 antibody detects endogenous levels of total MBD3

Reference Data

• Protein Families: Druggable Genome, Transcription Factors