DOK3 Rabbit Polyclonal Antibody

CAT#: TA347689

Rabbit Polyclonal Anti-DOK3 Antibody

Product Images

Western blot analysis on HepG2 cell lysate using DOK3 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-DOK3 Antibody: A synthesized peptide derived from human DOK3
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 58 kDa
• Gene Name: docking protein 3
• Database Link:
  NP_079148
  Entrez Gene 27261 MouseEntrez Gene 79930 Human
  UniProt ID Q7L591
• Background: Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP. May modulate Abl function. On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP. 4 isoforms of the human protein are produced by alternative splicing.
• Synonyms: DOKL
• Note: DOK3 Antibody detects endogenous levels of DOK3

Reference Data

• Protein Families: Druggable Genome