HEXIM1 Rabbit Polyclonal Antibody

CAT#: TA349449

Rabbit Polyclonal Anti-HEXIM1 Antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane 1-2: NIH/3T3 cell Mouse liver tissue lysates Primary antibody: TA349449 (HEXIM1 Antibody) at dilution 1/800 Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution Exposure time: 1 minute

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 500-2000
  WB positive control: NIH/3T3 cell, Mouse liver tissue lysates
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human HEXIM1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 41 kDa
• Gene Name: hexamethylene bis-acetamide inducible 1
• Database Link:
  NP_006451
  Entrez Gene 192231 MouseEntrez Gene 498008 RatEntrez Gene 10614 Human
  UniProt ID O94992
• Background: Hexamethylene bis-acetamide inducible 1 (HEXIM1) and Hexamethylene bis-acetamide inducible 2 (HEXIM2) comprise a family of proteins which inhibit positive transcription elongation factor b (P-TEFb) through association with 7SK. P-TEFb is composed of a catalytic subunit, Cdk9, and either Cyclin T1 or T2 as a regulatory subunit. This complex regulates eukaryotic gene expression at the level of elongation. The C-terminal domains of HEXIM proteins interact directly with each other. Via these domains, HEXIM1 and HEXIM2 form stable homo- and hetero-oligomers, which may aid in the formation of the 7SK small nuclear ribonucleic acid particle. Despite their similar functions, HEXIM1 and HEXIM2 exhibit distinct expression patterns in various established cell lines and human tissues.
• Synonyms: CLP1; EDG1; HIS1; MAQ1

Reference Data

• Protein Families: Transcription Factors