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xCT (SLC7A11) Rabbit Polyclonal Antibody
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Other products for "SLC7A11"
Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommended Dilution | WB: 200-1000 WB positive control: Human thyroid cancer and normal stomach tissue IHC: 10-50 Positive control: Human liver cancer Predicted cell location: Cytoplasm |
| Reactivities | Human, Mouse |
| Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human SLC7A11 |
| Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Predicted Protein Size | 55 kDa |
| Gene Name | solute carrier family 7 member 11 |
| Database Link | |
| Background | This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. |
| Synonyms | CCBR1; xCT |
| Reference Data | |
| Protein Families | Druggable Genome, Transmembrane |
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