EMA (MUC1) Mouse Monoclonal Antibody [Clone ID: SM3]

CAT#: TA353346L

Mouse monoclonal Anti-MUC1 Clone SM3

Specifications

Product Data

• Clone Name: SM3
• Recommended Dilution: ELISA ; FACS ; IHC
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Hydrogen fluoride deglycosylated milk mucin.
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: mucin 1, cell surface associated
• Database Link:
  NP_002447
  Entrez Gene 4582 Human
  UniProt ID P15941
• Background: MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoitic cell lineages. In the vast majority of human carcinomas, this protein is upregulated, poorly glycosylated and appears on the cell surface in a non-polarised fashion. SM3 antibody recognises this under-glycosylated form of MUC1 and is therefore tunour specific and may be relevant for breast cancer therapy. SM3 also detects MUC1 within colon and ovarian cancer and most adenocarcinomas and may be used for immunohistochemistry (reactive with methacarn fixed tissue), and immunotargeting.
• Synonyms: ADMCKD; ADMCKD1; CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1; SEC
• Note: The product of the MUC1 gene is the polymorphic epithelial mucin. SM3 reacts with a core protein epitope defined as PDTRP.

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane