FUT4 Mouse Monoclonal Antibody

CAT#: TA354954

Mouse anti CD15 Monoclonal Antibody

Specifications

Product Data

• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human
• Host: Mouse
• Isotype: IgM
• Clonality: Monoclonal
• Immunogen: The human myelomonocytic leukemia cells.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 59 kDa
• Gene Name: fucosyltransferase 4
• Database Link:
  NP_002024
  Entrez Gene 2526 Human
  UniProt ID P22083
• Background: CD15 is an antigen present on myelomonocytic cells and Lacto-Nfucopentose III (also known as hapten X). It is present on greater than 90% of granulocytes including neutrophils and eosinophils, and to a lesser degree, on monocytes. CD15 is expressed in Reed-Sternberg cells of Hodgkin’s disease (of the nodular sclerosis, mixed cellularity and lymphocyte-depleted subtypes). This antibody recognizes myeloid cells, mainly granulocytes but not on B cells, T cells, monocytes, erythrocytes or platelets. Positive staining for CD15 combined with a negative reaction for lymphocytic markers may provide support for Hodgkin’s disease. Fifty percent or more of adenocarcinomas have been described as showing significant cytoplasmic positivity for CD15. It does not detect most mesotheliomas.
• Synonyms: CD15; ELFT; FCT3A; FUC-TIV; FUTIV; LeX; SSEA-1

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Glycosphingolipid biosynthesis - lacto and neolacto series, Metabolic pathways