TTF1 (NKX2-1) Mouse Monoclonal Antibody [Clone ID: SPT24]

CAT#: TA355352

Thyroid Transcription Factor-1 Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: SPT24
• Applications: IHC
• Recommended Dilution: 1:200
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein corresponding to a 123 amino acid fragment of the N-terminal region of the TTF-1 molecule
• Specificity: Human thyroid transcription factor-1 (TTF-1)
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: NK2 homeobox 1
• Database Link:
  Entrez Gene 7080 Human
• Background: Thyroid Transcription Factor-1 (TTF-1) is a member of the homeodomain transcription factor family and plays a role in regulating genes expressed within the thyroid, lung and brain. These include thyroglobulin, thyroid peroxidase, Clara cell secretory protein and surfactant proteins. Human TTF-1 (38 kD) is a single polypeptide of 371 amino acids sharing 98% homology with the equivalent rat and mouse proteins. TTF-1 functions by binding to specific recognition sites in a manner that may be regulated by both the redox and phosphorylation status of the protein. In addition to its role as a tissue-specific transcriptional activator in adult organs, TTF-1 may also function in organogenesis. Gene targeting studies have shown TTF-1 to be essential for the proper development of the thyroid and lungs and abnormal expression may underline a number of congenital abnormalities.
• Synonyms: BCH; BHC; NK-2; NKX2.1; NKX2A; TEBP; TITF1; TTF-1; TTF1