PCDHA11 Rabbit Polyclonal Antibody

CAT#: TA356797

PCDHA11 Antibody - N-terminal region

Product Images

WB Suggested Anti-PCDHA11 Antibody Titration: 1.0 ug/ml Positive Control: 721_B Whole Cell

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Cow, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
  Homology: Cow: 93%; Guinea Pig: 77%; Horse: 92%; Human: 100%; Mouse: 93%; Pig: 85%; Rabbit: 86%; Rat: 91%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 85kDa
• Gene Name: protocadherin alpha 11
• Database Link:
  NP_114067
  Entrez Gene 56138 Human
  UniProt ID Q9Y5I1-2
• Background: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
• Synonyms: CNR7; CNRN7; CNRS7; CRNR7; PCDH-alpha-11; PCDH-ALPHA11

Reference Data

• Protein Families: Transmembrane