RAB43 Rabbit Polyclonal Antibody

CAT#: TA358956

RAB43 Antibody - C-terminal region

Product Images

WB Suggested Anti-RAB43 antibody Titration: 1 ug/mL Sample Type: Human OVCAR-3 Whole Cell

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human RAB43
• Specificity: Expected reactivity: Human
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 23 kDa
• Gene Name: RAB43, member RAS oncogene family
• Database Link:
  NP_940892.1
  Entrez Gene 339122 Human
  UniProt ID Q86YS6
• Background: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. RAB43 is involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. It plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
• Synonyms: ISY1; MGC90481; OTTHUMP00000174306; OTTHUMP00000174307; OTTHUMP00000174308; OTTHUMP00000174309; RAB11B; RAB41