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DPP1 (CTSC) Rabbit Polyclonal Antibody
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Other products for "CTSC"
Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommended Dilution | WB: 200-1000 WB positive control: Human placenta tissue IHC: 15-50 Positive control: Human Lymphoma Predicted cell location: Cytoplasm |
| Reactivities | Human |
| Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human CTSC |
| Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C. |
| Stability | 1 year |
| Predicted Protein Size | 52 kDa |
| Gene Name | cathepsin C |
| Database Link | |
| Background | The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. |
| Synonyms | CPPI; DPP-I; DPP1; DPPI; HMS; JP; JPD; PALS; PLS |
| Reference Data | |
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