alpha 1 Catenin (CTNNA1) Rabbit Monoclonal Antibody [Clone ID: R07-7D5]

CAT#: TA384056

CTNNA1 Rabbit monoclonal Antibody

Product Images

Western blot detection of alpha 1 Catenin in Rat Brain,C6,3T3,Hela cell lysates using alpha 1 Catenin Rabbit mAb(1:1000 diluted).Predicted band size:100kDa.Observed band size:100kDa.

Specifications

Product Data

• Clone Name: R07-7D5
• Applications: IP, WB
• Recommended Dilution: WB: 1/1000
  IP: 1/20
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human alpha 1 Catenin
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 100 kDa; Observed MW: 100 kDa
• Gene Name: catenin alpha 1
• Database Link:
  Entrez Gene 1495 Human
  UniProt ID P35221
• Background: Swiss-Prot Acc.P35221.Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
• Synonyms: alpha-catenin; alpha-E-catenin; alphaE-catenin; CAP102; FLJ36832; FLJ52416