HDAC5 Rabbit Polyclonal Antibody

CAT#: TA384402

HDAC5 Rabbit polyclonal Antibody

Product Images

Western Blot analysis of various cells using HDAC5 Polyclonal Antibody

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  Western Blot analysis of K562 cells using HDAC5 Polyclonal Antibody

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  Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using HDAC5 Antibody. The picture on the right is blocked with the synthesized peptide.

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  Western blot analysis of lysates from colo cells, using HDAC5 Antibody. The lane on the right is blocked with the synthesized peptide.

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: WB: 1/500-1/2000
  IHC: 1/100-1/300
  IF: 1/200-1/1000
  ELISA: 1/20000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The antiserum was produced against synthesized peptide derived from human HDAC5. AA range:464-513
• Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Observed MW (kDa):122
• Database Link:
  UniProt ID Q9UQL6
• Background: Swiss-Prot Acc.Q9UQL6.Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.