TTF1 (NKX2-1) Rabbit Monoclonal Antibody [Clone ID: R02-6A5]

CAT#: TA384876

Thyroid Transcription Factor 1 Rabbit monoclonal Antibody

Specifications

Product Data

• Clone Name: R02-6A5
• Applications: IHC, IP, WB
• Recommended Dilution: WB: 1/1000
  IHC: 1/50-1/100
  IP: 1/20
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human TTF1
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 39 kDa; Observed MW: 39 kDa
• Gene Name: NK2 homeobox 1
• Database Link:
  Entrez Gene 7080 Human
  UniProt ID P43699
• Background: Swiss-Prot Acc.P43699.Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 .
• Synonyms: BCH; BHC; NK-2; NKX2.1; NKX2A; TEBP; TITF1; TTF-1; TTF1