PP2A-alpha (PPP2CA) Rabbit Monoclonal Antibody [Clone ID: R06-8A4]

CAT#: TA385030

PP2A alpha/beta Rabbit monoclonal Antibody

Product Images

Western blot detection of PP2A alpha/beta in K562,Rat Brain,C6,3T3 cell lysates using PP2A alpha/beta Rabbit mAb(1:1000 diluted).Predicted band size:36kDa.Observed band size:36kDa.

Specifications

Product Data

• Clone Name: R06-8A4
• Applications: IP, WB
• Recommended Dilution: WB: 1/1000-1/100
  IP: 1/50
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human PP2A alpha
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 36 kDa; Observed MW: 36 kDa
• Gene Name: protein phosphatase 2 catalytic subunit alpha
• Database Link:
  Entrez Gene 5515 Human
  UniProt ID P67775
• Background: Swiss-Prot Acc.P67775.PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I . Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
• Synonyms: PP2A-alpha; PP2Ac; PP2CA; PP2Calpha; RP-C