TRIF (TICAM1) Rabbit Monoclonal Antibody [Clone ID: R02-2A9]
Other products for "TICAM1"
Specifications
Product Data | |
Clone Name | R02-2A9 |
Applications | IP, WB |
Recommended Dilution | WB: 1/1000 IP: 1/20 |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Monoclonal |
Immunogen | Recombinant protein of human TRIF |
Formulation | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
Concentration | lot specific |
Purification | Affinity Purified |
Conjugation | Unconjugated |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Stability | 1 year |
Predicted Protein Size | Calculated MW: 76 kDa; Observed MW: 98 kDa |
Gene Name | toll like receptor adaptor molecule 1 |
Database Link | |
Background | Swiss-Prot Acc.Q8IUC6.Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines . |
Synonyms | MGC35334; PRVTIRB; TICAM-1; TRIF |
Reference Data |
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