TRAF6 Rabbit Monoclonal Antibody [Clone ID: R09-3F4]

CAT#: TA385456

TRAF6 Rabbit monoclonal Antibody

Product Images

Western blot detection of TRAF6 in 293 cell lysates using TRAF6 Rabbit mAb(1:1000 diluted).Predicted band size:60KDa.Observed band size:60KDa.

Specifications

Product Data

• Clone Name: R09-3F4
• Applications: WB
• Recommended Dilution: WB: 1/1000-1/5000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human TRAF6
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 60 kDa; Observed MW: 60 kDa
• Gene Name: TNF receptor associated factor 6
• Database Link:
  Entrez Gene 7189 Human
  UniProt ID Q9Y4K3
• Background: Swiss-Prot Acc.Q9Y4K3.E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.
• Synonyms: MGC:3310; RNF85