CD105 (ENG) Rabbit Polyclonal Antibody

CAT#: TA590810

Rabbit Polyclonal CD105 Antibody

Product Images

ELISA: CD105 Antibody - Affinity Purified

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: WB: 1:5000-1:20000; ELISA: 1:100-1:2000; FC 1:10-1:1000; IHC: 1:10-1:2000; IHC-P 1:250-1:2000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DNA immunization. This antibody is specific for the C Terminus Region of the target protein.
• Formulation: 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
• Concentration: 1.1mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: endoglin
• Database Link:
  NP_000109
  Entrez Gene 2022 Human
  UniProt ID P17813
• Background: CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFAR-2 as a receptor for TGFA-1 and TGFA-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFA-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
• Synonyms: END; HHT1; ORW1
• Note: This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane