Mouse IL-25(IL-17E) ELISA Kit (48-well)
USD 290.00
3 Weeks*
Product Images
Specifications
Product Data | |
Format | 48-well strip plate |
Assay Type | Solid Phase Sandwich ELISA |
Assay Length | 3 hour |
Signal | Colorimetric |
Curve Range | 0.03 - 2.0 ng/mL |
Sample Type | Cell culture supernatant, serum, plasma (EDTA, citrate, heparin) |
Sample Volume | 20 uL |
Specificity | Natural and recombinant Mouse IL-25(IL-17E) Ligand |
Sensitivity | 15pg/mL |
Reactivities | Mouse |
Interference | No significant interference observed with available related molecules. |
Components |
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Background | IL-25 (also known as IL-17E) is a member of the IL-17 family of proinflammatory cytokines, which includes IL-17A, IL-17B, IL-17C, IL-17F and IL-17A/F. IL-17E is found at low levels in various peripheral tissues. It is a proinflammatory cytokine that promotes airway eosinophilia in mice. IL-17E plays a role in Th2 type inflammatory diseases, such as asthma and atopic dermatitis. IL-25 induces elevatedgene expression of IL-4, IL-5 and IL-13 in multiple tissues and results in T helper 2 (TH2)-type immune responses (increased serumIgE levels) and pathologic changes in the lungsand digestive tract with eosinophilic infiltrates, increased mucusproduction, epithelial cell hyperplasia and overall amplified allergicinflammation. IL-25 shares the receptor IL-17RB with IL-17B, although it binds with much higher affinity than IL-17B. |
Gene Symbol | Il25 |
Standard Curve |
Representative standard curve for IL-25/IL-17E ELISA. IL-25/IL-17E was diluted in serial two-fold steps in Sample Diluent.
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Documents
SDS |
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