Eps15 (NM_007943) Mouse Untagged Clone

CAT#: MC222461

Eps15 (untagged) - Mouse epidermal growth factor receptor pathway substrate 15 (Eps15), transcript variant 1, (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Eps15
• Synonyms: 2410112D09Rik
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC222461 representing NM_007943
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCTGCGGCAGCCCAGCTCTCCCTGACACAGTTGTCAAGTGGGAATCCTGTATATGAAAAATACTACA
  GACAGGTTGAGGCAGGCAATACTGGAAGGGTGTTGGCGTTAGATGCTGCTGCATTCCTGAAAAAGTCAGG
  GCTTCCAGACTTGATTCTTGGAAAGATTTGGGATTTAGCTGACACAGATGGCAAAGGTGTCCTGAGCAAA
  CAAGAATTCTTTGTTGCTTTACGGCTTGTGGCATGTGCTCAGAATGGACTGGAAGTTTCACTGAGTAGCC
  TAAGTCTGGCTGTTCCTCCACCAAGATTTCATGACTCCAGCAGTCCGTTGCTAACCAGTGGGCCCTCAGT
  TGCTGAGCTCCCGTGGGCTGTAAAGTCTGAAGATAAAGCCAAATATGATGCAATTTTTGACAGTTTAAGC
  CCAGTGGATGGATTTTTGTCTGGTGATAAAGTGAAACCAGTGTTGCTCAACTCTAAGTTACCTGTGGAAA
  TCCTTGGAAGAGTTTGGGAGTTGAGTGATATTGACCACGATGGAAAGCTGGACAGAGATGAGTTTGCAGT
  TGCCATGTTTTTGGTATACTGTGCACTGGAGAAAGAACCTGTGCCAATGTCCTTGCCTCCAGCCTTGGTG
  CCACCTTCTAAGAGAAAAACGTGGGTTGTATCCCCTGCAGAAAAAGCTAAATATGATGAAATTTTTCTGA
  AAACTGATAAGGATATGGATGGATATGTGTCTGGACTGGAGGTCCGTGAAACCTTCCTGAAAACAGGTTT
  ACCTTCTGCCTTGCTAGCCCACATTTGGTCACTATGTGACACAAAGGGCTGTGGGAAGCTTTCAAAAGAC
  CAGTTTGCCTTGGCTTTTCACTTAATCAATCAGAAGTTAATAAAAGGCATTGACCCTCCTCATAGTCTCA
  CTCCTGAGATGATTCCACCATCAGACAGATCCAGTTTACAAAAGAACATCACAGGATCAAGTCCTGTTGC
  AGATTTTTCTGCTATTAAGGAACTAGATACCCTTAACAATGAAATAGTTGACCTGCAGAGGGAAAAGAAC
  AATGTGGAGCAGGACCTTAAAGAGAAGGAAGACACAGTTAAGCAGAGGACCAGTGAGGTTCAGGATCTTC
  AAGATGAAGTTCAAAGGGAGAGTATTAATCTACAAAAACTGCAGGCCCAGAAGCAGCAGGTGCAGGAGCT
  CCTGGGTGAACTGGATGAGCAGAAAGCCCAGCTGGAGGAGCAGCTCCAGGAAGTCAGGAAAAAGTGTGCT
  GAGGAGGCCCAGCTGATTTCTTCCCTGAAAGCAGAAATAACTAGTCAAGAATCTCAGATCTCCAGTTATG
  AGGAAGAACTGTTGAAAGCTAGAGAAGAACTAAGTCGCCTACAACAAGAAACAGCACAATTGGAAGAAAG
  TGTGGAGTCAGGGAAGGCTCAGCTGGAACCTCTTCAGCAGCACCTACAAGAGTCACAACAGGAAATCAGC
  TCAATGCAAATGAGATTGGAAATGAAAGATCTGGAAACTGATAATAACCAATCAAATTGGAGCAGTAGCC
  CACAAAGCGTTCTTGTTAATGGTGCTACAGATTACTGTAGCCTCAGCACCAGCAGCAGTGAAACAGCCAA
  CTTCAACGAACATGCTGAAGGCCAAAACAACCTAGAGTCTGAACCCACACACCAGGAGTCCTCAGTAAGA
  AGTAGTCCTGAAATCGCACCTTCTGATGTGACTGATGAAAGTGAGGCTGTGACTGTGGCTGGTAATGAGA
  AAGTTACTCCGAGATTTGACGATGACAAGCACTCAAAAGAGGAAGATCCATTTAATGTAGAATCAAGTTC
  ACTGACAGATGCAGTTGCAGATACAAACTTGGATTTTTTCCAGTCTGATCCTTTTGTTGGCAGTGATCCT
  TTCAAGGATGATCCTTTTGGAAAAATTGATCCATTTGGTGGTGACCCTTTCAAAGGCTCAGATCCTTTTG
  CGTCTGATTGCTTCTTTAAGCAGACTTCTACTGATCCTTTTACCACTTCAAGTACGGACCCTTTCAGTGC
  ATCCAGCAACAGCAGTAATACATCGGTAGAAACTTGGAAGCACAATGACCCATTTGCTCCTGGTGGAACA
  GTTGTTGCTGCAGCGAGTGATTCAGCCACAGACCCTTTTGCTTCTGTTTTCGGAAATGAATCATTTGGAG
  ATGGATTTGCTGACTTCAGCACATTATCAAAGGTCAACAATGAAGATGCTTTTAATCCTACCATATCAAG
  TTCTACCAGCAGTGTGACCATTGCAAAACCTATGTTAGAGGAAACAGCCAGCAAGAGTGAAGATGTGCCT
  CCAGCACTGCCGCCCAAAGTTGGCACTCCAACAAGACCTTGCCCGCCACCCCCTGGGAAAAGACCCATCA
  ACAAATTGGATTCTTCTGATCCCCTTAAACTGAATGATCCATTTCAGCCTTTCCCAGGCAATGATAGTCC
  CAAAGAAAAAGATCCTGATATGTTTTGTGATCCATTCACTTCTTCTACCACTACCAATAAAGAGGCTGAC
  CCAAGCAATTTTGCTAACTTCAGTGCTTATCCCTCTGAAGAAGATATGATTGAATGGGCAAAAAGGGAAA
  GTGAGCGGGAAGAAGAACAGAGGCTTGCCAGACTAAATCAGCAGGAGCAAGAAGACTTGGAACTGGCCAT
  TGCA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_007943
• ORF Size: 2664 bp
• Insert Size: 2664
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_007943.3, NP_031969.1
• RefSeq Size: 2801
• RefSeq ORF: 2694
• Locus ID: 13858
• Gene Summary: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A). Isoform A mainly localizes to clathrin-coated pits at the plasma membrane.