Usp3 (NM_001302122) Mouse Untagged Clone

CAT#: MC226713

Usp3 (untagged) - Mouse ubiquitin specific peptidase 3 (Usp3), transcript variant 3

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Usp3
• Synonyms: AA409661; BC017156
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC226713 representing NM_001302122
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGCCTAACTTTAGGGGTTATCAGCAGCAGGATGCCCATGAATTCATGCGCTACCTTTTGGATCATCTAC
  ACTTAGAACTTCAGGGTGGCTTCAATGGTGTTTCCCGCTCAGCAATTCTACAGGAGAATTCTACACTGTC
  TGCAAGTAACAAATGCTGCATAAATGGAGCATCAACTGTTGTCACAGCAATATTTGGAGGAATTCTCCAG
  AACGAGGTCAACTGCCTCATATGTGGGACAGAGTCGAGGAAGTTTGATCCATTCCTAGATCTCTCCTTAG
  ATATTCCAAGTCAGTTCAGAAGCAAGCGCTCTAAGAATCAGGAAAATGGGCCAGTTTGCTCCTTAAGAGA
  TTGCCTTCGCAGCTTCACTGACCTAGAGGAACTTGATGAGACAGAGTTGTATATGTGCCATAAGTGCAAA
  AAGAAACAAAAGTCCACAAAGAAGTTTTGGATTCAAAAACTTCCCAAGGCACTGTGCTTGCACCTGAAAA
  GGTTTCACTGGACAGCATATTTAAGAAACAAAGTCGATACATACGTTCAATTCCCACTGAGAGGCCTGGA
  CATGAAGTGCTACCTACTAGAGCCGGAGAACAGTGGTCCAGACAGTTGCCTGTATGACCTCGCTGCTGTG
  GTTGTACACCATGGCTCTGGGGTTGGTTCTGGACATTACACAGCATATGCAGTTCACGAAGGCCGCTGGT
  TCCATTTCAATGACAGCACTGTGACAGTGACTGATGAGGAGACCGTTGGGAAGGCAAAGGCCTACATTCT
  GTTTTATGTGGAGCGTCAGGCCAGAGCTGGAGCAGAAAAACTGTAA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_001302122
• ORF Size: 816 bp
• Insert Size: 816
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This clone expresses the complete ORF with c-terminal tags of Myc-DDK.

Reference Data

• RefSeq: NM_001302122.1, NP_001289051.1
• RefSeq Size: 5388
• RefSeq ORF: 816
• Locus ID: 235441
• Gene Summary: The protein encoded by this gene is a chromatin-associated histone 2A and 2B deubiquitinating enzyme that negatively regulates the DNA damage response. Mice deficient for this enzyme have reduced hematopoietic stem cell reserves, demonstrating a requirement in hematopoietic stem cell homeostasis. In addition, knock down of protein levels results in spontaneous tumor development and shortened lifespan, consistent with a function in preserving chromosomal integrity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
  Transcript Variant: This variant (3) has multiple differences in the 5' UTR and coding region and uses a downstream start codon compared to variant 1. It encodes isoform 3, which has a shorter N-terminus compared to isoform 1.