Usp3 (NM_001302116) Mouse Untagged Clone

CAT#: MC227931

Usp3 (untagged) - Mouse ubiquitin specific peptidase 3 (Usp3), transcript variant 2

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Usp3
• Synonyms: AA409661; BC017156
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC227931 representing NM_001302116
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGAGTGTCCGCACCTCAGCTCCAGCGTCTGCATCGCCCCGGACTCAGCCAAGTTCCCCAACGGCTCCC
  CGTCGTCCTGGTGCTGCAGCGTGTGCAGGTCCAACAAAAGCCCCTGGGTCTGTTTGACTTGTTCAAGTGT
  CCACTGTGGAAGGTATGTGAATGGCCATGCAAAAAAACATTATGAAGATGCACAGATACCCTTACTCAAC
  CATAAGAGATCAGAAAAGCAGGAGAAAGCTCAGCATACAGTGTGTATGGATTGCAGTAGCTACAGCACAT
  ACTGTTATCGCTGTGACGATTTTGTGGTCAACGACACCAAGCTGGGCCTGGTACAGAAAGTGAGAGAACA
  CTTACAGAACTTGGAAAACTCAGCCTTTACAGCGGACAGGCACAGAAAAAGAAAATTATTGGAAAACTCA
  TCACTAAACAGCAAGTTATTAAAAGTAAATGGAAGTACGACTGCCATTTGTGCCACAGGCCTTCGAAATT
  TGGGCAACACTTGTTTCATGAATGCTATCCTTCAGTCACTCAGGTCTTTAGTAGAAGAGTTTAGAAAGAC
  ACTGTGTGCTTTATGGCAAGGCAGCCAGACTGCATTTAGTCCTGAGTCCTTGTTTTATGTTGTCTGGAAG
  ATCATGCCTAACTTTAGGGGTTATCAGCAGCAGGATGCCCATGAATTCATGCGCTACCTTTTGGATCATC
  TACACTTAGAACTTCAGGGTGGCTTCAATGGTGTTTCCCGCTCAGCAATTCTACAGGAGAATTCTACACT
  GTCTGCAAGTAACAAATGCTGCATAAATGGAGCATCAACTGTTGTCACAGCAATATTTGGAGGAATTCTC
  CAGAACGAGGTCAACTGCCTCATATGTGGGACAGAGTCGAGGAAGTTTGATCCATTCCTAGATCTCTCCT
  TAGATATTCCAAGTCAGTTCAGAAGCAAGCGCTCTAAGAATCAGGAAAATGGGCCAGTTTGCTCCTTAAG
  AGATTGCCTTCGCAGCTTCACTGACCTAGAGGAACTTGATGAGACAGAGTTGTATATGTGCCATAAGTGC
  AAAAAGAAACAAAAGTCCACAAAGAAGTTTTGGATTCAAAAACTTCCCAAGGCACTGTGCTTGCACCTGA
  AAAGGTTTCACTGGACAGCATATTTAAGAAACAAAGTCGATACATACGTTCAATTCCCACTGAGAGGCCT
  GGACATGAAGTGCTACCTACTAGAGCCGGAGAACAGTGGTCCAGACAGTTGCCTGTATGACCTCGCTGCT
  GTGGTTGTACACCATGGCTCTGGGGTTGGTTCTGGACATTACACAGCATATGCAGTTCACGAAGGCCGCT
  GGTTCCATTTCAATGACAGCACTGTGACAGTGACTGATGAGGAGACCGTTGGGAAGGCAAAGGCCTACAT
  TCTGTTTTATGTGGAGCGTCAGGCCAGAGCTGGAGCAGAAAAACTGTAA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_001302116
• ORF Size: 1449 bp
• Insert Size: 1449
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This clone expresses the complete ORF with c-terminal tags of Myc-DDK.

Reference Data

• RefSeq: NM_001302116.1, NP_001289045.1
• RefSeq Size: 5480
• RefSeq ORF: 1449
• Locus ID: 235441
• Gene Summary: The protein encoded by this gene is a chromatin-associated histone 2A and 2B deubiquitinating enzyme that negatively regulates the DNA damage response. Mice deficient for this enzyme have reduced hematopoietic stem cell reserves, demonstrating a requirement in hematopoietic stem cell homeostasis. In addition, knock down of protein levels results in spontaneous tumor development and shortened lifespan, consistent with a function in preserving chromosomal integrity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
  Transcript Variant: This variant (2) lacks an in-frame exon in the coding region. This results in a shorter protein (isoform 2), compared to isoform 1.