Gpx3 (NM_022525) Rat Untagged Clone

CAT#: RN211963

Gpx3 (untagged ORF) - Rat glutathione peroxidase 3 (Gpx3), (Note, selenocysteine protein, internal stop codon, see reference data summary)

Specifications

Product Data

• Type: Rat Untagged Clone
• Symbol: Gpx3
• Synonyms: GPx-3; GPx-P; Gpxp; GSHPx-3; GSHPx-P
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >RN211963 representing NM_022525
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCCCGGATCCTTCGGGCATCCTGCCTCCTGTCCCTGCTCCTGGCCGGGTTTGTTCCGCCGGGCCGGG
  GACAAGAGAAGTCCAAGACAGACTGCCATGGCGGTATGAGCGGTACCATCTACGAGTATGGAGCCCTTAC
  CATCGATGGGGAGGAATACATTCCTTTTAAGCAGTATGCTGGCAAATACATCCTCTTTGTCAACGTAGCC
  AGCTACTGAGGTCTGACAGACCAATACCTTGAACTGAATGCACTACAAGAAGAACTTGGCCCATTCGGCC
  TGGTCATTCTGGGCTTCCCTTGCAACCAATTTGGCAAACAGGAGCCAGGCGAGAACTCGGAGATCCTGCC
  TAGTCTCAAGTACGTTCGACCGGGTGGGGGCTTTGTGCCTAATTTCCAGCTCTTTGAGAAAGGAGACGTG
  AACGGGGAGAAAGAGCAGAAGTTCTACACTTTCCTGAAGAACTCCTGCCCTCCCACTGCGGAACTCCTGG
  GCTCACCTGGCCGCCTCTTTTGGGAACCCATGAAGATCCATGACATCCGCTGGAACTTTGAGAAGTTCCT
  GGTGGGGCCAGATGGCATACCAATTATGCGCTGGTACCACCGGACCACAGTCAGCAACGTCAAGATGGAC
  ATCCTGTCCTATATGAGGCGGCAGGCAGCCCTGGGGGCCAGAGGGAAGTAA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_022525
• ORF Size: 681 bp
• Insert Size: 681
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). The expression of this clone is not guaranteed due to the nature of selenoproteins.

Reference Data

• RefSeq: NM_022525.3, NP_071970.2
• RefSeq Size: 1488
• RefSeq ORF: 681
• Locus ID: 64317
• Gene Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted and is predominantly expressed in rat kidney, which appears to be the major source of the enzyme in plasma. Dysregulation of this isozyme has been associated with obesity-related metabolic complications. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Aug 2016]