PTP alpha (PTPRA) (NM_002836) Human Untagged Clone

CAT#: SC109671

PTPRA (untagged)-Human protein tyrosine phosphatase, receptor type, A (PTPRA), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PTPRA
• Synonyms: HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA; PTPRL2; R-PTP-alpha; RPTPA
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC109671 sequence for NM_002836 edited (data generated by NextGen Sequencing)
  ATGGATTCCTGGTTCATTCTTGTTCTGCTCGGCAGTGGTCTGATATGTGTCAGTGCCAAC
  AATGCTACCACAGTTGCACCTTCTGTAGGAATTACAAGATTAATTAACTCATCAACGGCA
  GAACCAGTTAAAGAAGAGGCCAAAACTTCAAATCCAACTTCTTCACTAACTTCTCTTTCT
  GTGGCACCAACATTCAGCCCAAATATAACTCTGGGACCCACCTATTTAACCACTGTCAAT
  TCTTCAGACTCTGACAATGGGACCACAAGAACAGCAAGCACCAATTCTATAGGCATTACA
  ATTTCACCAAATGGAACGTGGCTTCCAGATAACCAGTTCACGGATGCCAGAACAGAACCC
  TGGGAGGGGAATTCCAGCACCGCAGCAACCACTCCAGAAACTTTCCCTCCTTCAGGTAAT
  TCTGACTCGAAGGACAGAAGAGATGAGACACCAATTATTGCGGTGATGGTGGCCCTGTCC
  TCTCTGCTAGTGATCGTGTTTATTATCATAGTTTTGTACATGTTAAGGTTTAAGAAATAC
  AAGCAAGCTGGGAGCCATTCCAATTCTTTCCGCTTATCCAACGGCCGCACTGAGGATGTG
  GAGCCCCAGAGTGTGCCACTTCTGGCCAGATCCCCAAGCACCAACAGGAAATACCCACCC
  CTGCCCGTGGACAAGCTGGAAGAGGAAATTAACCGGAGAATGGCAGACGACAATAAGCTC
  TTCAGGGAGGAATTCAACGCTCTCCCTGCATGTCCTATCCAGGCCACCTGTGAGGCTGCT
  TCCAAGGAGGAAAACAAGGAAAAAAATCGATATGTAAACATCTTGCCTTATGACCACTCT
  AGAGTCCACCTGACACCGGTTGAAGGGGTTCCAGATTCTGATTACATCAATGCTTCATTC
  ATCAACGGCTACCAAGAAAAGAACAAATTCATTGCTGCACAAGGACCAAAAGAAGAAACG
  GTGAATGATTTCTGGCGGATGATCTGGGAACAAAACACAGCCACCATCGTCATGGTTACC
  AACCTGAAGGAGAGAAAGGAGTGCAAGTGCGCCCAGTACTGGCCAGACCAAGGCTGCTGG
  ACCTATGGGAATATTCGGGTGTCTGTAGAGGATGTGACTGTCCTGGTGGACTACACAGTA
  CGGAAGTTCTGCATCCAGCAGGTGGGCGACATGACCAACAGAAAGCCACAGCGCCTCATC
  ACTCAGTTCCACTTTACCAGCTGGCCAGACTTTGGGGTGCCTTTTACCCCGATCGGCATG
  CTCAAGTTCCTCAAGAAGGTGAAGGCCTGTAACCCTCAGTATGCAGGGGCCATCGTGGTC
  CACTGCAGTGCAGGTGTAGGGCGTACAGGTACCTTTGTCGTCATTGATGCCATGCTGGAC
  ATGATGCATACAGAACGGAAGGTGGACGTGTATGGCTTTGTGAGCCGGATCCGGGCACAG
  CGCTGCCAGATGGTGCAAACCGATATGCAGTATGTCTTCATATACCAAGCCCTTCTGGAG
  CATTATCTCTATGGAGATACAGAACTGGAAGTGACCTCTCTAGAAACCCACCTGCAGAAA
  ATTTACAACAAAATCCCAGGGACCAGCAACAATGGATTAGAGGAGGAGTTTAAGAAGTTA
  ACATCAATCAAAATCCAGAATGACAAGATGCGGACTGGAAACCTTCCAGCCAACATGAAG
  AAGAACCGTGTTTTACAGATCATTCCATATGAATTCAACAGAGTGATCATTCCAGTTAAG
  CGGGGCGAAGAGAATACAGACTATGTGAACGCATCCTTTATTGATGGCTACCGGCAGAAG
  GACTCCTATATCGCCAGCCAGGGCCCTCTTCTCCACACAATTGAGGACTTCTGGCGAATG
  ATCTGGGAGTGGAAATCCTGCTCTATCGTGATGCTAACAGAACTGGAGGAGAGAGGCCAG
  GAGAAGTGTGCCCAGTACTGGCCATCTGATGGACTGGTGTCCTATGGAGATATTACAGTG
  GAACTGAAGAAGGAGGAGGAATGTGAGAGCTACACCGTCCGAGACCTCCTGGTCACCAAC
  ACCAGGGAGAATAAGAGCCGGCAGATCCGGCAGTTCCACTTCCATGGCTGGCCTGAAGTG
  GGCATCCCCAGTGACGGAAAGGGCATGATCAGCATCATCGCCGCCGTGCAGAAGCAGCAG
  CAGCAGTCAGGGAACCACCCCATCACCGTGCACTGCAGCGCCGGGGCAGGAAGGACGGGG
  ACCTTCTGTGCCCTGAGCACCGTCCTGGAGCGTGTGAAAGCAGAGGGGATTTTGGATGTC
  TTCCAGACTGTCAAGAGCCTGCGGCTACAGAGGCCACACATGGTCCAGACACTGGAACAG
  TATGAGTTCTGCTACAAGGTGGTGCAGGAGTATATTGATGCATTCTCAGATTATGCCAAC
  TTCAAGTAA
  
  Clone variation with respect to NM_002836.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002836 unedited
  AATACGACTCACTATAGGGCGGCCGCGACATTCGCACGAGGGCAGTTCAAATAACTAAGG
  ACACATGTTCAAAGAGCATAATTAACTTTTTAAAAGAAGCTAATAAGCATGGATTCCTGG
  TTCATTCTTGTTCTGCTCGGCAGTGGTCTGATATGTGTCAGTGCCAACAATGCTACCACA
  GTTGCACCTTCTGTAGGAATTACAAGATTAATTAACTCATCAACGGCAGAACCAGTTAAA
  GAAGAGGCCAAAACTTCAAATCCAACTTCTTCACTAACTTCTCTTTCTGTGGCACCAACA
  TTCAGCCCAAATATAACTCTGGGACCCACCTATTTAACCACTGTCAATTCTTCAGACTCT
  GACAATGGGACCACAAGAACAGCAAGCACCAATTCTATAGGCATTACAATTTCACCAAAT
  GGAACGTGGCTTCCAGATAACCAGTTCACGGATGCCAGAACAGAACCCTGGGAGGGGAAT
  TCCAGCACCGCAGCAACCACTCCAGAAACTTTCCCTCCTTCAGGTAATTCTGACTCGAAG
  GACAGAAGAGATGAGACACCAATTATTGCGGTGATGGTGGCCCTGTCCTCTCTGTAGTGA
  TCGTGTTATTATCATAGTTTTGTACATGTTAAGGTTTAAGAAATACAGCAGCTGGGAGCC
  TTCCAATTCTTTTCGCTTATCCAACGCCGACTGAAGATGTGGAGCCCCAAATGTGCCACT
  TCTGGCCAGATCCNCAGCACCACAGAANTACCCACCTTGCCCGTGACAGCTGGAAGAAGA
  AATAACCGAGAATGGCGACGACATAGCTCTCAGGNAGGATTCACGCTCTCCTGATGTCTA
  TCAGCCACTGGAAGCTGTTCCAGGGAGAAAACAGAAAAACGTTGTAACATCTGCTTTGAC
  ACTTTAAGCACTGACGNGGGGGGC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002836 unedited
  NGGAATTACTGACACTTTTAATTCTCCATAAAACATGGNAAAAGGACTATCAGTGCTAAC
  ACATTTACATATAAAATTTCCACCTAATAGGTAATAGAAGCCTATGTACCAATTTCTAAA
  ACAGTTATAAGATATATACACAATTTGGGGTATATTAACAAAACAGAATATTACAAAATA
  TTAAAGGCAATCCTCCTGGTCCACGGACCCTTGTTGCCGCTTACTTGAAGTTGGCATAAT
  CTGAGAATGCATCAATATACTCCTGCACCACCTTGTAGCAGAACTCATACTGTTCCAGTG
  TCTGGACCATGTGTGGCCTCTGTAGCCGCAGGCTCTTGACAGTCTGGAAGACATCCAAAA
  TCCCCTCTGCTTTCACACGCTCCAGGACGGTGCTCAGGGCACAGAAGGTCCCCGTCCTTC
  CTGCCCCGGCGCTGCAGTGCACGGTGATGGGGTGGTTCCCTGACTGCTGCTGCTGCTTCT
  GCACGGCGGCGATGATGCTGATCATGCCCTTTCCGTCACTGGGGATGCCCACTTCAGGCC
  AGCCATGGAAGTGGAACTGCCGGATCTGCCGGCTCTTATTCTCCCTGGTGTTGGTGACCA
  GGAGGTCTCGGACGGTGTAGCTCTCACATTCCTCCTCCTTCTTCAGTTCCACTGTAATAT
  CTCCATAGGACACCAGTCCATCAGATGGCCAGTACTGGGCACACTTCTCCTGGCCTCTCT
  CCTTCAGTTCTGTTAGCATCACGATAGAGCAGGATTTCCACTCCCAGATCATTCGCCAGA
  AGTCCTCAATTGTGTGGGAGAGAAGGGCCCTGNCTGGCGATATANNGAGNCCTTCTGNCG
  GTAGCCATCAATAAGGNATGCGTCACATAGTCTGTATTCTCTTCGCCCCGCTTTACTGGA
  ATGATCACTCTGNTGAATNCATATGGATGATCTGTN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002836
• Insert Size: 2820 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002836.2, NP_002827.1
• RefSeq Size: 3643 bp
• RefSeq ORF: 2409 bp
• Locus ID: 5786
• Cytogenetics: 20p13
• Domains: Y_phosphatase, PTPc_motif
• Protein Families: Druggable Genome, Phosphatase, Transmembrane
• Gene Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]'
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).