Claudin 12 (CLDN12) (NM_012129) Human Untagged Clone

CAT#: SC115525

CLDN12 (untagged)-Human claudin 12 (CLDN12), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CLDN12
• Synonyms: claudin 12; OTTHUMP00000067944
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC115525 sequence for NM_012129 edited (data generated by NextGen Sequencing)
  ATGGGCTGTCGGGATGTCCACGCAGCCACAGTCCTTTCCTTCCTGTGTGGAATCGCCTCA
  GTAGCAGGCCTCTTTGCAGGGACTCTGCTTCCCAACTGGAGAAAATTACGATTGATCACA
  TTCAACAGAAACGAGAAGAACCTGACTGTTTACACAGGCCTGTGGGTGAAATGTGCCCGG
  TATGACGGGAGCAGTGACTGCCTGATGTACGACACTACTTGGTACTCATCAGTTGACCAG
  CTGGACCTGCGTGTCCTCCAGTTTGCCCTACCCCTCAGCATGCTGATCGCCATGGGTGCC
  CTGCTGCTCTGCCTGATTGGAATGTGCAACACTGCCTTCAGGTCCTCGGTGCCCAACATC
  AAACTGGCCAAGTGTCTGGTCAATAGTGCAGGTTGCCACCTGGTGGCTGGGCTGCTATTT
  TTCCTGGCAGGTACTGTGAGCCTCTCCCCATCTATCTGGGTCATCTTTTATAACATCCAT
  CTGAACAAGAAGTTTGAGCCAGTCTTTTCATTTGACTATGCAGTGTATGTCACTATTGCT
  AGTGCTGGGGGCCTGTTTATGACTTCCCTTATACTATTTATTTGGTATTGTACATGCAAA
  TCTTTGCCTTCTCCTTTCTGGCAACCATTGTACTCCCATCCACCCAGTATGCATACTTAC
  TCACAGCCCTATTCAGCACGCTCTCGCCTCTCTGCCATTGAAATTGACATTCCAGTAGTT
  TCACACACCACTTAA
  
  Clone variation with respect to NM_012129.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_012129 unedited
  TTCACATATTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGCGCACTTCCT
  GGGACGCTGAGAGGGAGACGCTCCAAGAGGCTCCTCAGTGTGGGCGAGTAAAATGCCCTG
  CGTGTGAGAAGCAGGCTCAGATTATTGCTACTCTGTATTCAGATCTTCATGTGTCTCTTC
  TAAGCTGAATAAAGCTGTTTTGGAACTGTCAGGTACCTCAAAGCGTAATCTGACTGACAG
  TACTCCACAAGCTTGCCTGCCATGGGCTGTCGGGATGTCCACGCAGCCACAGTCCTTTCC
  TTCCTGTGTGGAATCGCCTCAGTAGCAGGCCTCTTTGCAGGGACTCTGCTTCCCAACTGG
  AGAAAATTACGATTGATCACATTCAACAGAAACGAGAAGAACCTGACTGTTTACACAGGC
  CTGTGGGTGAAATGTGCCCGGTATGACGGGAGCAGTGACTGCCTGATGTACGACACTACT
  TGGTACTCATCAGTTGACCAGCTGGACCTGCGTGTCCTCCAGTTTGCCCTACCCCTCAGC
  ATGCTGATCGCCATGGGTGCCCTGCTGCTCTGCCTGATTGGAATGTGCAACACTGCCTTC
  AGGTCCTCGGTGCCCAACATCAAACTGGCCAAGTGTCTGGTCAATAGTGCAGGTTGCCAC
  CTGGTGGCTGGGCTGCTATTTTTCCTGGCAGGTACTGTGAGCCTCTCCCCTCTATCTGGG
  TCATCTTTTATAACATCCATCTGAACAAGAAGTTTGAGCCAGTCTTTTCATTTGACTATG
  CAGNGTATGTCACTATTGCTAGTGCTGGGGGCCTGNTTATGACTTCCCTATACTATNTAT
  NTGGTATTGTACATGCCAATCTTTGCCTTCTCCTTTTCTGGCACCATTNGTACTCCATCC
  ACCCATATGCATACTTACTNACAGCCTATNNANNACGCTCTCGCTCTCTGCCATTGAAAT
  GCATNCCAGAN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_012129 unedited
  CTATGGACCGCGGACCGTCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTGTAAAAAAC
  ATCTTTTAATAAACATTATATAAGTACAGCGACACTTTTATTGAGGTTTTACATTGTAGT
  TTACAGCAAATATACTATCCATTGTAGTGTATATGTACAAGTAAAGTAAACTTATGTTTG
  TTTTCTCTCCCATGGCTGGATAAACCAAATCTGATACATCCAGATTTAAAGTTGTTTTCC
  AAGTTGGTTTACCATAAAAGGACTTTAACAATAATAGGCTTTTAATAACATAAAGGTATC
  CCTCCCATCACAATGAGAGCTTGACGAGGGCTCAAAAGTGACTTCAAAAACTGTAAATAA
  TTATTTTCCTTGGGTGGCTTTAAAAATAGCTACTGATATCAGATCAAAAACACTTAATAA
  AAAATACAATAAGGAAACATCTGTTAGTCTAGTGAATCCACAATAAATACCGATTTGACG
  GCTCTAGATTACAAAAGCCTATGATGCTTATATGAAACGTAATCGGTTATACTTACAATG
  CGGTGTACTAAAAAAACCGGCTGATATGTTATAAACTGAATCTCCCTTTATACAACCTTG
  TTTATGCTCGAGTATTACGGGGGTGGGAGAATTTTGCATCCCGCATGAATAAACCTCACG
  AGCTGGGACTGCACTTAATCAACACGCGACAACCCGCTTATGTGCAAATTCTACCTCGGC
  GGGCGCTATCAAGAATTAAGATCAGTTCCTTTGTTAAAAAACGCAAGGATCAAACACCGA
  CGAAATCCGACGCGCGTGCATACAAATCCAAACCTTATGTGACTTGCCGGGACAGTATAG
  TAAATTATTAACCTTGTTTACTCACGCCGATTAAATTTCGGTGATACTTTGTGTAAAAAT
  AACGAATCCGGTAACGAATACCGCAGGATACGCACAAATGCCCGGAGTCCTACACCACGG
  GTTACTACCCGTCCGTTCGAGCAGTG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_012129
• ORF Size: 735 bp
• Insert Size: 3700
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_012129.2, NP_036261.1
• RefSeq Size: 3493
• RefSeq ORF: 735
• Locus ID: 9069
• Protein Families: Transmembrane
• Gene Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found. [provided by RefSeq, Sep 2011]
  Transcript Variant: This variant (3) lacks an exon in the 5' UTR, as compared to variant 1.