RGS6 (NM_004296) Human Untagged Clone

CAT#: SC117457

RGS6 (untagged)-Human regulator of G-protein signaling 6 (RGS6), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RGS6
• Synonyms: GAP; HA117; S914
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC117457 sequence for NM_004296 edited (data generated by NextGen Sequencing)
  ATGGCTCAAGGATCCGGGGATCAAAGAGCAGTGGGGGTTGCTGACCCAGAGGAGAGTTCT
  CCAAACATGATCGTTTACTGCAAAATTGAAGACATCATTACAAAGATGCAAGATGACAAG
  ACAGGGGGTGTGCCCATCAGAACAGTCAAGAGCTTTCTCTCCAAAATCCCCAGTGTCGTC
  ACAGGTACTGACATTGTGCAGTGGCTTATGAAGAACCTTTCCATTGAGGACCCAGTTGAA
  GCAATACACTTGGGGAGCCTTATCGCTGCCCAGGGCTACATCTTTCCAATCTCAGACCAT
  GTTCTCACCATGAAGGATGATGGCACCTTTTATCGTTTCCAGGCTCCGTACTTCTGGCCT
  TCGAACTGCTGGGAACCTGAAAACACTGACTATGCCATCTATCTCTGTAAGAGGACAATG
  CAAAATAAAGCAAGGCTGGAACTGGCAGATTATGAAGCAGAAAACTTAGCAAGACTCCAG
  AGGGCCTTTGCGAGGAAGTGGGAATTCATCTTTATGCAAGCAGAAGCACAAGTAAAGATT
  GACCGAAAAAAAGACAAGACAGAAAGGAAAATTTTGGATAGTCAAGAACGAGCCTTTTGG
  GATGTCCACAGGCCTGTGCCAGGCTGTGTGAACACAACAGAAATGGATATCCGAAAATGT
  CGACGTTTGAAGAATCCACAAAAGGTTAAAAAGTCCGTGTATGGCGTGACTGAAGAGTCC
  CAGGCACAGAGCCCGGTGCATGTACTCAGCCAACCAATCAGGAAAACAACAAAAGAGGAC
  ATCCGGAAACAGATAACATTTTTGAACGCACAGATCGACAGACATTGTTTGAAAATGTCC
  AAAGTGGCTGAAAGTTTAATTGCCTACACGGAACAATATGTGGAATATGACCCTTTGATA
  ACACCAGCTGAGCCATCCAACCCTTGGATCAGCGATGACGTTGCTTTGTGGGACATAGAG
  ATGAGCAAAGAGCCCAGCCAACAGCGAGTAAAAAGATGGGGCTTCTCTTTCGATGAGATA
  TTGAAGGACCAGGTGGGGCGGGACCAGTTTCTACGATTCCTGGAGTCCGAATTCAGTTCA
  GAAAACCTCAGGTTCTGGCTGGCTGTCCAAGATCTTAAGAAACAACCCCTACAGGATGTG
  GCCAAGAGGGTAGAAGAAATCTGGCAAGAGTTTCTGGCTCCAGGGGCTCCAAGTGCAATC
  AACCTGGATTCTCACAGCTATGAGATAACCAGTCAAAATGTCAAAGATGGAGGGAGATAT
  ACATTTGAAGACGCCCAGGAGCACATCTACAAGCTGATGAAGAGTGACAGCTATGCCCGC
  TTCCTCCGGTCAAATGCTTACCAGGATTTGCTGCTGGCCAAGAAGAAGGGAAAGTCGCTG
  GCGGGCAAGCGCCTCACGGGCCTGATGCAGTCCTCCTGA
  
  Clone variation with respect to NM_004296.5
  546 g=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004296 unedited
  CTATAGGGCGGCCGCGAATTCGCACGAGGGCCGCGCGTCCTCGCGGGCCCGGGGCTTCGC
  TCTTCGCTCGCTGAGCCCCTGCGCTCGCCACCACGGAAACTCGGAAAGAGGAGGCGAGGC
  TGTGGGGAGCGGCGCGGAGACGGACTAGACTTCCCCTCCGCCCCCAAGAGGCTGCCGGTC
  CCCGGTTCCCTGGGCTTCTCCAGCTTTATCATGAACCTGGCGCAAGGTTGGCTTTAGGAA
  AAATTCTGGAGCCAGAGGGAGAGTCAAGGCAATTCTTTGGTTGCTAAGTGTGAGTGAAGA
  CACTCAGGATGGCTCAAGGATCCGGGGATCAAAGAGCAGTGGGGGTTGCTGACCCAGAGG
  AGAGTTCTCCAAACATGATCGTTTACTGCAAAATTGAAGACATCATTACAAAGATGCAAG
  ATGACAAGACAGGGGGTGTGCCCATCAGAACAGTCAAGAGCTTTCTCTCCAAAATCCCCA
  GTGTCGTCACAGGTACTGACATTGTGCAGTGGCTTATGAAGAACCTTTCCATTGAGGACC
  CAGTTGAAGCAATACACTTGGGGAGCCTTATCGCTGCCCAGGGCTACATCTTTCCAATCT
  CAGACCATGTTCTCACCATGAAGGATGATGGCACCTTTTATCGTTTCCAGGCTCCGTACT
  TCTGGCCTTCGAACTGCTGGGAAACCTGAAACACTGACTATGCCATCTATCTCTGNTAGA
  AGGACATGCAAAATTAAGCAAGGCTGGAACTGGCAGATTATGAAGCAAATACTTAGCAAG
  ATCCAAAGGGCCTTTGCGAGGAAGTGGGATTCATCTTATGCAAGCAGATCCCAGTTAAGA
  TGGCCGAAAAAGACAGACAGAAGGAAATTTGGATAGT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004296 unedited
  CTATGGACCGGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTGGGTTCAA
  GTCATTTATTTTTAAACTGTACCAGCATGTTTGGTTCTGGGGTCCAATTCCCACATTCCA
  GAAAAATAAACTAAAGAGAACCACATGCACTAAGAGGAGGCCCTTCCGATGAGTCCGCGA
  TCATGCGGTGAGTGGGCTTAAAGTATACAACAGGGACCCCTGGTATGGAGCAGGGCCTTC
  CCTTCCCAGACAGCTGACAGCAGCTGGCTCTGAGCCCTCATCGGGGCTGGGGAGAGGGCC
  AAGCCCTGGTCATTTGGACCCTGTCCCCGTATAGACCCGGGCCCTTTATTGCTACATTTG
  CTACTTTGCTACTTTATGGCCCCTGGGTCTAGCCCAGGGGATGCCTTATCACTGGGTGGC
  ACTAAAGAGTAGGCTGCTGGCATCTGCTGATGCTATGGTTACACGAGCACAGGCCCCTCT
  TCAGAGGGCCCCATGGTGAGCTATTACCGACTCGTATGGCCCCTATTCAACTGACCCCCA
  TGGCCTTTGCTACATATTCAACTCGGCGCCACCCCCCTTTTGAAGCTGGTGGCGCATTAT
  CTCCCCCCCACTCCACAGTTCCCACCTCCTGTACCTTGCAGCAAACCTTTCTTAACTACA
  ATCTTGCAGGGCCCAACGGCACCAGAGCCCTTAATCCTCTTCCCTTTCCTGGGAAGGCTC
  TCCTGGCGCGGGCTTTCCGACCCCATTCTCTGGCACCCAACCCGACGGCGCCCCTCAAGG
  AAAACTTCACCTTCTTCATGAACCAGGTGACCACCCGGCGGCCCCTTCTTGCTCAACGCC
  CGCTCGCGCCGGAATTTCCAACCCCACCATTCCCCCCCGCACCCACCACTGGAATCTGCC
  CCCCGCGATTCCACTCTCCACACCCGCCCACACCTGACAAAGCTACTCCAGTACGTCTGA
  CCCCTTCTCACAACCCTAG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004296
• ORF Size: 1419 bp
• Insert Size: 4700
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_004296.3, NP_004287.3
• RefSeq Size: 3105
• RefSeq ORF: 1419
• Locus ID: 9628
• Domains: RGS, DEP, G-gamma
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known. [provided by RefSeq, Mar 2011]
  Transcript Variant: This variant (2) lacks the in-frame penultimate coding exon compared to variant 1. This results in a shorter isoform (2, also known as RGS6Lalpha2), missing an 18 aa protein segment compared to isoform 1.