SCUBE3 (NM_152753) Human Untagged Clone

CAT#: SC126481

SCUBE3 (untagged)-Human signal peptide, CUB domain, EGF-like 3 (SCUBE3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SCUBE3
• Synonyms: CEGF3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_152753 edited
  CTCTCTCCCGGCGAAGCTGGGAATTGGGTGGGATTACACGGAGCAGCCCCGCCGCCGCCG
  CTGGCAGAGGCCGGCTTGGAGAGGGCGGGGGTTCCCCTCCGTCAGTCGCCCCTGGCGCCC
  CTCGCCTTGTCGCACTCTCCGCCTCGCTCTCCCCGACGTCCGGCCAGGAGGAGCCGGTAG
  CATCGGGAGCCTCGCGCCGAGGGCGCCGCGGTCCGCGCCCCGCGACTGCAGCCCCCGGCC
  TGGCCCCGGCGGGGCGCCCCCTCCCCTCCCCCTCCTGCGAGCTGGGATCCGGCCGGCTTC
  CGCCCTCCCCTGGCCGCGAGACCGGCCCCGGCGGCTGGGCCGCCAGTAGCTCCAGCCATG
  GGCTCGGGGCGCGTACCCGGGCTCTGCCTGCTTGTCCTGCTGGTCCACGCCCGCGCCGCC
  CAGTACAGCAAAGCCGCGCAAGATGTGGATGAGTGTGTGGAGGGGACTGACAACTGCCAC
  ATCGATGCTATCTGCCAGAACACCCCGAGGTCATACAAGTGCATCTGCAAGTCTGGCTAC
  ACAGGGGACGGCAAACACTGCAAAGACGTGGATGAGTGCGAGCGAGAGGATAATGCAGGT
  TGTGTGCATGACTGTGTCAACATCCCTGGCAATTACCGGTGTACCTGCTATGATGGATTC
  CACCTGGCACATGACGGACACAACTGTCTGGATGTGGACGAGTGTGCCGAGGGCAACGGC
  GGCTGTCAGCAGAGCTGTGTCAACATGATGGGCAGCTATGAGTGCCACTGCCGGGAAGGC
  TTCTTCCTCAGCGACAACCAGCATACCTGTATCCAGCGGCCAGAAGGAATGAACTGCATG
  AACAAGAACCACGGCTGTGCCCACATTTGCCGGGAGACACCCAAGGGGGGTATTGCCTGT
  GAATGCCGTCCTGGCTTTGAGCTTACCAAGAACCAACGGGACTGTAAATTGACATGCAAC
  TATGGTAACGGCGGCTGCCAGCACACGTGTGATGACACAGAGCAGGGTCCCCGGTGCGGC
  TGCCATATCAAGTTTGTGCTCCATACCGACGGGAAGACATGCATCGAGACCTGTGCTGTC
  AACAACGGGGGCTGTGACAGTAAGTGCCATGATGCAGCGATTGGTGTCCACTGCACCTGC
  CCTGTGGGCTTCATGCTGCAGCCAGACAGGAAGACGTGCAAAGATATAGATGAGTGCCGC
  TTAAACAACGGGGGCTGTGACCATATTTGCCGCAACACAGTGGGCAGCTTCGAATGCAGT
  TGCAAGAAAGGCTATAAGCTTCTCATCAATGAGAGGAACTGCCAGGATATAGACGAGTGT
  TCCTTTGATCGAACCTGTGACCACATATGTGTCAACACACCAGGAAGCTTCCAGTGTCTC
  TGCCATCGTGGCTACCTGTTGTATGGTATCACCCACTGTGGGGATGTGGATGAATGCAGC
  ATCAACCGGGGAGGTTGCCGCTTTGGCTGCATCAACACTCCTGGCAGCTACCAGTGTACC
  TGCCCAGCAGGCCAGGGTCGGCTGCACTGGAATGGCAAAGATTGCACAGAGCCACTGAAG
  TGTCAGGGCAGTCCTGGGGCCTCGAAAGCCATGCTCAGCTGCAACCGGTCTGGCAAGAAG
  GACACCTGTGCCCTGACCTGTCCCTCCAGGGCCCGATTTTTGCCAGAGTCTGAGAATGGC
  TTCACGGTGAGCTGTGGGACCCCCAGCCCCAGGGCTGCTCCAGCCCGAGCTGGCCACAAT
  GGGAACAGCACCAACTCCAACCACTGCCATGAGGCTGCAGTGCTGTCCATTAAACAACGG
  GCCTCCTTCAAGATCAAGGATGCCAAATGCCGTTTGCACCTGCGAAACAAAGGCAAAACA
  GAGGAGGCTGGCAGAATCACAGGGCCAGGTGGTGCCCCCTGCTCTGAATGCCAGGTCACC
  TTCATCCACCTTAAGTGTGACTCCTCTCGGAAGGGCAAGGGCCGACGGGCCCGGACCCCT
  CCAGGCAAAGAGGTCACAAGGCTCACCCTGGAACTGGAGGCAGAGGTCAGAGCCGAAGAA
  ACCACAGCCAGCTGTGGGCTGCCCTGCCTCCGACAGCGAATGGAACGGCGGCTGAAAGGA
  TCCCTGAAGATGCTCAGAAAGTCCATCAACCAGGACCGCTTCCTGCTGCGCCTGGCAGGC
  CTTGATTATGAGCTGGCCCACAAGCCGGGCCTGGTAGCCGGGGAGCGAGCAGAGCCGATG
  GAGTCCTGTAGGCCCGGGCAGCACCGTGCTGGGACCAAGTGTGTCAGCTGCCCGCAGGGA
  ACGTATTACCACGGCCAGACGGAGCAGTGTGTGCCATGCCCAGCGGGCACCTTCCAGGAG
  AGAGAAGGGCAGCTCTCCTGCGACCTTTGCCCTGGGAGTGATGCCCACGGGCCTCTTGGA
  GCCACCAACGTCACCACGTGTGCAGGTCAGTGCCCACCTGGCCAACACTCTGTAGATGGG
  TTCAAGCCCTGTCAGCCATGCCCACGTGGCACCTACCAACCTGAAGCAGGACGGACCCTA
  TGCTTCCCTTGTGGTGGGGGCCTCACCACCAAGCATGAAGGGGCCATTTCCTTCCAAGAC
  TGTGACACCAAAGTCCAGTGCTCCCCAGGGCACTACTACAACACCAGCATCCACCGCTGT
  ATTCGCTGTGCCATGGGCTCCTATCAGCCCGACTTCCGTCAGAACTTCTGCAGCCGCTGT
  CCAGGAAACACAAGCACAGACTTTGATGGCTCTACCAGTGTGGCCCAATGCAAGAATCGT
  CAGTGTGGTGGGGAGCTGGGTGAGTTCACTGGCTATATTGAGTCCCCCAACTACCCGGGC
  AACTACCCAGCTGGTGTGGAGTGCATCTGGAACATCAACCCCCCACCCAAGCGCAAGATC
  CTTATCGTGGTACCAGAGATCTTCCTGCCATCTGAGGATGAGTGTGGGGACGTCCTCGTC
  ATGAGAAAGAACTCATCCCCATCCTCCATTACCACTTATGAGACCTGCCAGACCTACGAG
  CGTCCCATTGCCTTCACTGCCCGTTCCAGGAAGCTCTGGATCAACTTCAAGACAAGCGAG
  GCCAACAGCGCCCGTGGCTTCCAGATTCCCTATGTTACCTATGATGAGGACTATGAGCAG
  CTGGTAGAAGACATTGTGCGAGATGGCCGGCTCTATGCCTCTGAAAACCACCAGGAGATT
  TTAAAGGACAAGAAGCTCATCAAGGCCTTCTTTGAGGTGCTAGCCCACCCCCAGAACTAC
  TTCAAGTACACAGAGAAACACAAGGAGATGCTGCCAAAATCCTTCATCAAGCTGCTCCGC
  TCCAAAGTTTCCAGCTTCCTGAGGCCCTACAAATAGTAACCCTAGGCTCAGAGACCCAAT
  TTTTTAAGCCCCCAGACTCCTTAGCCCTCAGAGCCGGCAGCCCCCTACCCTCAGACAAGG
  AACTCTCTCCTCTCTTTTTGGAGGGAAAAAAAAAATATCACTACACAAACCAGGCACTCT
  CCCTTTCTGTCTTTCTAGTTTCCTTTCCTTGTCTCTCTCTGCCTGCCTCTCTACTGTTCC
  CCCTTTTCTAACACACTACCTAGAAAAGCCATTCAGTACTGGCTCTAGTCCCCGTGAGAT
  GTAAAGAAACAGTACAGCCCCTTCCACTGCCCATTTTACCAGCTCACATTCCCGACCCCA
  TCAGCTTGGAAGGGTGCTAGAGGCCCATCAAGGAAGTGGGTCTGGTGGGAAACGGGGAGG
  GGAAAGAAGGGCTTCTGCCATTATAGGGTTGTGCCTTGCTAGTCAGGGGCCAAAATGTCC
  CCTGGCTCTGCTCCCTAGGGTGATTCTAACAGCCCAGGGTCCTGCCAAAGAAGCCTTTGA
  TTTACAGGCTTAATGCCAGCACCAGTCCTCTGGGGCACATGGTTTGAGCTCTGGACTTCC
  CACATGGCCAGCTTTCTTGTCTATACAGATCCTCTCTTTCTTTCCCTACGTCTGCCTGGG
  GTCTACTCCATAAGGGTTTACAAATGGCCCACAACACTGAGTTAGTGGACACCGGCTAAA
  TGAGGAAGAGCAGCAGGCATTGTCATGGTGAATGCCCCGCTGTAGCTCCCTGAGAGAAAG
  ACTGTAACTCTGCAGGACAGAAACAAGGTTTTAAAGCATTGCCAAAAAAAAAAAAAAAAA
  AA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_152753 unedited
  NGGGCGGTTCGGATTTTGTATACGACTCACTATAGGCGGCCGCGNAATTCGCACGAGGCT
  CTCTCCCGGCGAAGCTGGGAATTGGGTGGGATTACACGGAGCAGCCCCGCCGCCGCCGCT
  GGCAGAGGCCGGCTTGGAGAGGGCGGGGGTTCCCCTCCGTCAGTCGCCCCTGGCGCCCCT
  CGCCTTGTCGCACTCTCCGCCTCGCTCTCCCCGACGTCCGGCCAGGAGGAGCCGGTAGCA
  TCGGGAGCCTCGCGCCGAGGGCGCCGCGGTCCGCGCCCCGCGACTGCAGCCCCCGGCCTG
  GCCCCGGCGGGGCGCCCCCTCCCCTCCCCCTCCTGCGAGCTGGGATCCGGCCGGCTTCCG
  CCCTCCCCTGGCCGCGAGACCGGCCCCGGCGGCTGGGCCGCCAGTAGCTCCAGCCATGGG
  CTCGGGGCGCGTACCCGGGCTCTGCCTGCTTGTCCTGCTGGTCCACGCCCGCGCCGCCCA
  GTACAGCAAAGCCGCGCAAGATGTGGATGAGTGTGTGGAGGGGACTGACAACTGCCACAT
  CGATGCTATCTGCCAGAACACCCCGAGGTCATACAAGTGCATCTGCAAGTCTGGCTACAC
  AGGGGACGGCAAACACTGCAAAGACGTGGATGAGTGCGAGCGAGAGGATAATGCAGGTTG
  TGTGCATGACTGTGTCAACATCCCTGGCAATTACCGGTGTACCTGCTATGATGGATTCCA
  CCTGGCACATGACGGACACAACTGTCTGGATGTGGACCAGTGTGCCGAGGGCAACGGCGG
  CTGTCAGCAGAGCTGTGTCAACATGATGGGCAGCTATGAGTGCCACTTGCCGGGAAGGCT
  TCTTCCTTAGCGACAACCAGCATACCCTGTATCCAGCGGCCAGAATGA
  
• Restriction Sites: Please inquire
• ACCN: NM_152753
• ORF Size: 2982 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_152753.2, NP_689966.2
• RefSeq Size: 5115
• RefSeq ORF: 2982
• Locus ID: 222663
• Protein Families: Druggable Genome, Secreted Protein
• Gene Summary: This gene encodes a member of the signal peptide, complement subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1 and epidermal growth factor-like domain containing protein family. Overexpression of this gene in human embryonic kidney cells results in secretion of a glycosylated form of the protein that forms oligomers and tethers to the cell surface. This gene is upregulated in lung cancer tumor tissue compared to healthy tissue and is associated with loss of the epithelial marker E-cadherin and with increased expression of vimentin, a mesenchymal marker. In addition, the protein encoded by this gene is a transforming growth factor beta receptor ligand, and when secreted by cancer cells, it can be cleaved in vitro to release the N-terminal epidermal growth factor-like repeat domain and the C-terminal complement subcomponents C1r/C1s domain. Both the full length protein and C-terminal fragment can bind to the transforming growth factor beta type II receptor to promote the epithelial-mesenchymal transition and tumor angiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).