ING3 (NM_019071) Human Untagged Clone

CAT#: SC128111

ING3 (untagged)-Human inhibitor of growth family, member 3 (ING3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ING3
• Synonyms: Eaf4; ING2; MEAF4; p47ING3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_019071 edited
  TACCATGTTGTACCTAGAAGACTATCTGGAAATGATTGAGCAGCTTCCTATGGATCTGCG
  GGACCGCTTCACGGAAATGCGCGAGATGGACCTGCAGGTGCAGAATGCAATGGATCAACT
  AGAACAAAGAGTCAGTGAATTCTTTATGAATGCAAAGAAAAATAAACCTGAGTGGAGGGA
  AGAGCAAATGGCATCCATCAAAAAAGACTACTATAAAGCTTTGGAAGATGCAGATGAGAA
  GGTTCAGTTGGCAAACCAGATATATGACTTGGTAGATCGACACTTGAGAAAGCTGGATCA
  GGAACTGGCTAAGTTTAAAATGGAGCTGGAAGCTGATAATGCTGGAATTACAGAAATATT
  AGAGAGGCGATCTTTGGAATTAGACACTCCTTCACAGCCAGTGAACAATCACCATGCTCA
  TTCACATACTCCAGTGGAAAAAAGGAAATATAATCCAACTTCTCACCATACGACAACAGA
  TCATATTCCTGAAAAGAAATTTAAATCTGAAGCTCTTCTATCCACCCTTACGTCAGATGC
  CTCTAAGGAAAATACACTAGGTTGTCGAAATAATAATTCCACAGCCTCTTCTAACAATGC
  CTACAATGTGAATTCCTCCCAACCTCTGGGATCCTATAACATTGGCTCGTTATCTTCAGG
  AACTGGTGCAGGGGCAATTACCATGGCAGCTGCTCAAGCAGTTCAGGCTACAGCTCAGAT
  GAAGGAGGGACGAAGAACATCAAGTTTAAAAGCCAGTTATGAAGCATTTAAGAATAATGA
  CTTTCAGTTGGGAAAAGAATTTTCAATGGCCAGGGAAACAGTTGGCTATTCATCATCTTC
  GGCACTTATGACAACATTAACACAGAATGCCAGTTCATCAGCAGCCGACTCACGGAGTGG
  TCGAAAGAGCAAAAACAACAACAAGTCTTCAAGCCAGCAGTCATCATCTTCCTCCTCCTC
  TTCTTCCTTATCATCGTGTTCTTCATCATCAACTGTTGTACAAGAAATCTCTCAACAAAC
  AACTGTAGTGCCAGAATCTGATTCAAATAGTCAGGTTGATTGGACTTACGACCCAAATGA
  ACCTCGATACTGCATTTGTAATCAGGTATCTTATGGTGAGATGGTGGGATGTGATAACCA
  AGATTGCCCTATAGAATGGTTCCATTATGGCTGCGTTGGATTGACAGAGGCACCAAAAGG
  CAAATGGTACTGTCCACAGTGCACTGCTGCAATGAAGAGAAGAGGCAGCAGACACAAATA
  AAGGTGGTCCTTTTGTTTGATGAAGAAATAAACTTCAGCTGAAGATTTTATATAGGACTT
  TAAAAAGAAGAGAAGAGAAAGAAGAAACAATGCATTTCCAGGCAACCACTTAAAGGATTT
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_019071 unedited
  GGAGTTCACAATTTGTATACGACTCACTATAGGCGGCCGCGNATTCAAATCTGGTACCAT
  GTTGTACCTAGAAGACTATCTGGAATGATTGAGCAGCTTCCTATGGATCTGCGGGACCGC
  TTCACGGAAATGCGCGAGATGGACCTGCAGGTGCAGAATGCAATGGATCAACTAGAACAA
  AGAGTCAGTGAATTCTTTATGAATGCAAAGAAAAATAAACCTGAGTGGAGGGAAGAGCAA
  ATGGCATCCATCAAAAAAGACTACTATAAAGCTTTGGAAGATGCAGATGAGAAGGTTCAG
  TTGGCAAACCAGATATATGACTTGGTAGATCGACACTTGAGAAAGCTGGATCAGGAACTG
  GCTAAGTTTAAAATGGAGCTGGAAGCTGATAATGCTGGAATTACAGAAATATTAGAGAGG
  CGATCTTTGGAATTAGACACTCCTTCACAGCCAGTGAACAATCACCATGCTCATTCACAT
  ACTCCAGTGGAAAAAAGGAAATATAATCCAACTTCTCACCATACGACAACAGATCATATT
  CCTGAAAAGAAATTTAAATCTGAAGCTCTTCTATCCACCCTTACGTCAGATGCCTCTAAG
  GAAAATACACNTANGTTGTCGAAATAATAATTCCACAGCCTCTTCTAACAATGCCTACAA
  TGTGAATTCCTCCCACCTCTGGGATCCTATAACATTGGCTCGTTATCTTCAGGAACTGGT
  GCAGGGGCAATTACCATGGCAGCTGTNCAAGCAGTTCAGGCTACAGCTCAGATGAAAGAG
  GNACGAAGAAACATCAAGTTAANAGCCAGTTATGAAGCATTTAAGATAATGACTTTCAGT
  TGGGAAAAGATTTTTCATGGCCAGGGAAACAGTTGGCTATTCATCATCTTCGCACTTATG
  ACACAT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_019071 unedited
  NNCCATGGAATGGCACTTCCAGGNCCAGGNANAGCACTGGGGNAGGGTCACAGGGATGCC
  ACCCGGGATCTGTTCAGGAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGAAATCCT
  TTAAGTGGTTGCCTGGAAATGCATTGTTTCTTCTTTCTCTTCTCTTCTTTTTAAAGTCCT
  ATATAAAATCTTCAGCTGAAGTTTATTTCTTCATCAAACAAAAGGACCACCTTTATTTGT
  GTCTGCTGCCTCTTCTCTTCATTGCAGCAGTGCACTGTGGACAGTACCATTTGCCTTTTG
  GTGCCTCTGTCAATCCAACGCAGCCATAATGGAACCATTCTATAGGGCAATCTTGGTTAT
  CACATCCCACCATCTCACCATAAGATACCTGATTACAAATGCAGTATCGAGGTTCATTTG
  GGTCGTAAGTCCAATCAACCTGACTATTTGAATCAGATTCTGGCACTACAGTTGTTTGTT
  GAGAGATTTCTTGTACAACAGTTGATGATGAAGAACACGATGATAAGGAAGAAGAGGAGG
  AGGAAGATGATGACTGCTGGCTTGAAGACTTGTTGTTGTTTTTGCTCTTTCGACCACTCC
  GTGAGTCGGCTGCTGATGAACTGGCATTCTGTGTTAATGTTGTCATAAGTGCCGAAGATG
  ATGAATAGCCAACTGTTTCCCTGGCCATTGAAAATTCTTTTCCCAACTGAAAGTCATTAT
  TCTTAAATGCTTCATAACTGGCTTTTAACCTTGATGTTCTTCGTCCCTCCTTCATCTGAG
  CTGTAGCCTGAACTGCTTGAGCAGCTGCCATGGTAATTGCCCCTGCACCAGTTCCTGAAG
  AAACGAGCCAATGTTATANGATCCCCANAGGTTGGGGAGGAATTCACATTGNTAGCA
  
• Restriction Sites: Please inquire
• ACCN: NM_019071
• ORF Size: 1257 bp
• Insert Size: 1400
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_019071.2, NP_061944.2
• RefSeq Size: 2221
• RefSeq ORF: 1257
• Locus ID: 54556
• Domains: PHD
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).