IRAK (IRAK1) (NM_001025243) Human Untagged Clone

CAT#: SC302380

IRAK1 (untagged)-Human interleukin-1 receptor-associated kinase 1 (IRAK1), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IRAK1
• Synonyms: IRAK; pelle
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001025243 edited
  CCCAGGCCCGCGCCCGCCGCGGCCCTGAGAGGCCCCGGCAGGTCCCGGCCCGGCGGCGGC
  AGCCATGGCCGGGGGGCCGGGCCCGGGGGAGCCCGCAGCCCCCGGCGCCCAGCACTTCTT
  GTACGAGGTGCCGCCCTGGGTCATGTGCCGCTTCTACAAAGTGATGGACGCCCTGGAGCC
  CGCCGACTGGTGCCAGTTCGCCGCCCTGATCGTGCGCGACCAGACCGAGCTGCGGCTGTG
  CGAGCGCTCCGGGCAGCGCACGGCCAGCGTCCTGTGGCCCTGGATCAACCGCAACGCCCG
  TGTGGCCGACCTCGTGCACATCCTCACGCACCTGCAGCTGCTCCGTGCGCGGGACATCAT
  CACAGCCTGGCACCCTCCCGCCCCGCTTCCGTCCCCAGGCACCACTGCCCCGAGGCCCAG
  CAGCATCCCTGCACCCGCCGAGGCCGAGGCCTGGAGCCCCCGGAAGTTGCCATCCTCAGC
  CTCCACCTTCCTCTCCCCAGCTTTTCCAGGCTCCCAGACCCATTCAGGGCCTGAGCTCGG
  CCTGGTTCCAAGCCCTGCTTCCCTGTGGCCTCCACCGCCATCTCCAGCCCCTTCTTCTAC
  CAAGCCAGGCCCAGAGAGCTCAGTGTCCCTCCTGCAGGGAGCCCGCCCCTCTCCGTTTTG
  CTGGCCCCTCTGTGAGATTTCCCGGGGCACCCACAACTTCTCGGAGGAGCTCAAGATCGG
  GGAGGGTGGCTTTGGGTGCGTGTACCGGGCGGTGATGAGGAACACGGTGTATGCTGTGAA
  GAGGCTGAAGGAGAACGCTGACCTGGAGTGGACTGCAGTGAAGCAGAGCTTCCTGACCGA
  GGTGGAGCAGCTGTCCAGGTTTCGTCACCCAAACATTGTGGACTTTGCTGGCTACTGTGC
  TCAGAACGGCTTCTACTGCCTGGTGTACGGCTTCCTGCCCAACGGCTCCCTGGAGGACCG
  TCTCCACTGCCAGACCCAGGCCTGCCCACCTCTCTCCTGGCCTCAGCGACTGGACATCCT
  TCTGGGTACAGCCCGGGCAATTCAGTTTCTACATCAGGACAGCCCCAGCCTCATCCATGG
  AGACATCAAGAGTTCCAACGTCCTTCTGGATGAGAGGCTGACACCCAAGCTGGGAGACTT
  TGGCCTGGCCCGGTTCAGCCGCTTTGCCGGGTCCAGCCCCAGCCAGAGCAGCATGGTGGC
  CCGGACACAGACAGTGCGGGGCACCCTGGCCTACCTGCCCGAGGAGTACATCAAGACGGG
  AAGGCTGGCTGTGGACACGGACACCTTCAGCTTTGGGGTGGTAGTGCTAGAGACCTTGGC
  TGGTCAGAGGGCTGTGAAGACGCACGGTGCCAGGACCAAGTATCTGGTGTACGAGAGGCT
  AGAGAAGCTGCAGGCAGTGGTGGCGGGGGTGCCCGGGCATTTGGAGGCCGCCAGCTGCAT
  CCCCCCTTCCCCGCAGGAGAACTCCTACGTGTCCAGCACTGGCAGAGCCCACAGTGGGGC
  TGCTCCATGGCAGCCCCTGGCAGCGCCATCAGGAGCCAGTGCCCAGGCAGCAGAGCAGCT
  GCAGAGAGGCCCCAACCAGCCCGTGGAGAGTGACGAGAGCCTAGGCGGCCTCTCTGCTGC
  CCTGCGCTCCTGGCACTTGACTCCAAGCTGCCCTCTGGACCCAGCACCCCTCAGGGAGGC
  CGGCTGTCCTCAGGGGGACACGGCAGGAGAATCGAGCTGGGGGAGTGGCCCAGGATCCCG
  GCCCACAGCCGTGGAAGGACTGGCCCTTGGCAGCTCTGCATCATCGTCGTCAGAGCCACC
  GCAGATTATCATCAACCCTGCCCGACAGAAGATGGTCCAGAAGCTGGCCCTGTACGAGGA
  TGGGGCCCTGGACAGCCTGCAGCTGCTGTCGTCCAGCTCCCTCCCAGGCTTGGGCCTGGA
  ACAGGACAGGCAGGGGCCCGAAGAAAGTGATGAATTTCAGAGCTGATGTGTTCACCTGGG
  CAGATCCCCCAAATCCGGAAGTCAAAGTTCTCATGGTCAGAAGTTCTCATGGTGCACGAG
  TCCTCAGCACTCTGCCGGCAGTGGGGGTGGGGGCCCATGCCCGCGGGGGAGAGAAGGAGG
  TGGCCCTGCTGTTCTAGGCTCTGTGGGCATAGGCAGGCAGAGTGGAACCCTGCCTCCATG
  CCAGCATCTGGGGGCAAGGAAGGCTGGCATCATCCAGTGAGGAGGCTGGCGCATGTTGGG
  AGGCTGCTGGCTGCACAGACCCGTGAGGGGAGGAGAGGGGCTGCTGTGCAGGGGTGTGGA
  GTAGGGAGCTGGCTCCCCTGAGAGCCATGCAGGGCGTCTGCAGCCCAGGCCTCTGGCAGC
  AGCTCTTTGCCCATCTCTTTGGACAGTGGCCACCCTGCACAATGGGGCCGACGAGGCCTA
  GGGCCCTCCTACCTGCTTACAATTTGGAAAAGTGTGGCCGGGTGCGGTGGCTCACGCCTG
  TAATCCCAGCACTTTGGGAGGCCAAGGCAGGAGGATCGCTGGAGCCCAGTAGGTCAAGAC
  CAGCCAGGGCAACATGATGAGACCCTGTCTCTGCCAAAAAATTTTTTAAACTATTAGCCT
  GGCGTGGTAGCGCACGCCTGTGGTCCCAGCTGCTGGGGAGGCTGAAGTAGGAGGATCATT
  TATGCTTGGGAGGTCGAGGCTGCAGTGAGTCATGATTGTATGACTGCACTCCAGCCTGGG
  TGACAGAGCAAGACCCTGTTTCAAAAAGAAAAACCCTGGGAAAAGTGAAGTATGGCTGTA
  AGTCTCATGGTTCAGTCCTAGCAAGAAGCGAG
  
• Restriction Sites: Please inquire
• ACCN: NM_001025243
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to differ from the protein associated to this reference by two amino acids.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001025243.1, NP_001020414.1
• RefSeq Size: 3352 bp
• RefSeq ORF: 1902 bp
• Locus ID: 3654
• Cytogenetics: Xq28
• Protein Families: Druggable Genome, Protein Kinase, Transcription Factors
• Protein Pathways: Apoptosis, Neurotrophin signaling pathway, Toll-like receptor signaling pathway
• Gene Summary: 'This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'
  Transcript Variant: This variant (3) lacks an in-frame exon, as compared to variant 1. The encoded isoform 3 thus lacks an internal segment, as compared to isoform 1.