GALR2 (NM_003857) Human Untagged Clone

CAT#: SC303390

GALR2 (untagged)-Human galanin receptor 2 (GALR2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: GALR2
• Synonyms: GAL2-R; GALNR2; GALR-2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003857 edited
  GCTGCAGGAGCCCGGGCAGCCTCGGGGTCAGCGGCACCATGAACGTCTCGGGCTGCCCAG
  GGGCCGGGAACGCGAGCCAGGCGGGCGGCGGGGGAGGCTGGCACCCCGAGGCGGTCATCG
  TGCCCCTGCTCTTCGCGCTCATCTTCCTCGTGGGCACCGTGGGCAACACGCTGGTGCTGG
  CGGTGCTGCTGCGCGGCGGCCAGGCGGTCAGCACTACCAACCTGTTCATCCTTAACCTGG
  GCGTGGCCGACCTGTGTTTCATCCTGTGCTGCGTGCCCTTCCAGGCCACCATCTACACCC
  TGGACGGCTGGGTGTTCGGCTCGCTGCTGTGCAAGGCGGTGCACTTCCTCATCTTCCTCA
  CCATGCACGCCAGCAGCTTCACGCTGGCCGCCGTCTCCCTGGACAGGTATCTGGCCATCC
  GCTACCCGCTGCACTCCCGCGAGCTGCGCACGCCTCGAAACGCGCTGGCAGCCATCGGGC
  TCATCTGGGGGCTGTCGCTGCTCTTCTCCGGGCCCTACCTGAGCTACTACCGCCAGTCGC
  AGCTGGCCAACCTGACCGTGTGCCATCCCGCGTGGAGCGCCCCTCGCCGCCGCGCCATGG
  ACATCTGCACCTTCGTCTTCAGCTACCTGCTTCCTGTGCTGGTTCTCGGCCTGACCTACG
  CGCGCACCTTGCGCTACCTCTGGCGCGCCGTCGACCCGGTGGCCGCGGGCTCGGGTGCCC
  GGCGCGCCAAGCGCAAGGTGACACGCATGATCCTCATCGTGGCCGCGCTCTTCTGCCTCT
  GCTGGATGCCCCACCACGCGCTCATCCTCTGCGTGTGGTTCGGCCAGTTCCCGCTCACGC
  GCGCCACTTATGCGCTTCGCATCCTCTCGCACCTGGTCTCCTACGCCAACTCCTGCGTCA
  ACCCCATCGTTTACGCGCTGGTCTCCAAGCACTTCCGCAAAGGCTTCCGCACGATCTGCG
  CGGGCCTGCTGGGCCGTGCCCCAGGCCGAGCCTCGGGCCGTGTGTGCGCTGCCGCGCGGG
  GCACCCACAGTGGCAGCGTGTTGGAGCGCGAGTCCAGCGACCTGTTGCACATGAGCGAGG
  CGGCGGGGGCCCTTCGTCCCTGCCCCGGCGCTTCCCAGCCATGCATCCTCGAGCCCTGTC
  CTGGCCCGTCCTGGCAGGGCCCAAAGGCAGGCGACAGCATCCTGACGGTTGATGTGGCCT
  GAAAGCACTTAGCGGGCGCGCTGGGATGTCACAGAGTTGGAG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003857 unedited
  NAACGTTCGCATTTGTATACGACTCACTATAGGCGGCCGCGATTCGCCCTTACCCANACG
  GCTGCAGGAGCCCGGGCAGCCTCGGGGTCAGCGGCACCATGAACGTCTCGGGCTGCCCAG
  GGGCCGGGAACGCGAGCCAGGCGGGCGGCGGGGGAGGCTGGCACCCCGAGGCGGTCATCG
  TGCCCCTGCTCTTCGCGCTCATCTTCCTCGTGGGCACCGTGGGCAACACGCTGGTGCTGG
  CGGTGCTGCTGCGCGGCGGCCAGGCGGTCAGCACTACCAACCTGTTCATCCTTAACCTGG
  GCGTGGCCGACCTGTGTTTCATCCTGTGCTGCGTGCCCTTCCAGGCCACCATCTACACCC
  TGGACGGCTGGGTGTTCGGCTCGCTGCTGTGCAAGGCGGTGCACTTCCTCATCTTCCTCA
  CCATGCACGCCAGCAGCTTCACGCTGGCCGCCGTCTCCCTGGACAGGTATCTGGCCATCC
  GCTACCCGCTGCACTCCCGCGAGCTGCGCACGCCTCGAAACGCGCTGGCAGCCATCGGGC
  TCATCTGGNGGCTGTCGCTGCTCTTCTCCGGGCCCTACCTGAGCTACTACCGCCAGTCGC
  AGCTGGCCAACCTGACCGTGTGCCATCCCGCGTGGAGCGCCCCTCGCCGCCGCGCCATGG
  ACATCTGCACCTTCGTCTTCAGCTACCTGCTTTCTGTGCTGGTTCTCGGCCTGACCTACG
  CGCGCACCTTGCGCTACCTCTGGCGCGCCGTCGACCCGGTGGCCGCGGGCTCGGGTTGCC
  CCGCGCGCCAAGCGCAAGGTGACACGCATGATCCTCATCGGGGCCGCGCTCTTCTGCCTC
  TGCTGGATGCCCCACAAGCGCTCATCCTTTGGGTGTGGTTCGGCCATTCCGGTTTAAGCC
  CGCAATT
  
  3' Read Nucleotide Sequence

  >OriGene 3' genomic read for NM_003857 unedited
  ATCGGAATGGCAACTTCCAGGNCCAGNAAAGCACTGGNGGNAGGGGTCACAGGGNATGCC
  ACCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGACAAGCTT
  GATATCGGTACCAGATCTGAATTCGCCCTTCTCCAACTCTGTGACATCCCAGCGCGCCCG
  CTAAGTGCTTTCAGGCCACATCAACCGTCAGGATGCTGTCGCCTGCCTTTGGGCCCTGCC
  AGGACGGGCCAGGACAGGGCTCGAGGATGCATGGCTGGGAAGCGCCGGGGCAGGGACGAA
  GGGCCCCCGCCGCCTCGCTCATGTGCAACAGGTCGCTGGACTCGCGCTCCAACACGCTGC
  CACTGTGGGTGCCCCGCGCGGCAGCGCACACACGGCCCGAGGCTCGGCCTGGGGCACGGC
  CCAGCAGGCCCGCGCAGATCGTGCGGAAGCCTTTGCGGAAGTGCTTGGAGACCAGCGCGT
  AAACGATGGGGTTGACGCAGGAGTTGGCGTANGAGACCAGGTGCGAGAGGATGCGAAGCG
  CATAAGTGGCGCGCGTGAGCGGGAACTGGCCGAACCACACGCAGAGGATGAGCGCGTGGT
  GNGGCATCCAGCAGAGGCAGAAGAGCGCGGCCACGATGAGGATCATGCGTGTCACCTTGC
  GCTTGGCGCGCCCGGGCACCCGAGCCCGCGGCCACCCGGGTCGACGGCGCGNCAGAAGTA
  GCGCAAGGTGCGCGCGGTAGTCANGCCGAGAACCAGCACAGGAAGCAGGTAGCTGAAGAC
  GAAAGTGCAAATGTCCATGGCCCGGCGGCCAGGGGCGCTCCACGCGGGGAAGGCCCAN
  
• Restriction Sites: Please inquire
• ACCN: NM_003857
• ORF Size: 1164 bp
• Insert Size: 1200
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.

Reference Data

• RefSeq: NM_003857.2, NP_003848.1
• RefSeq Size: 1309
• RefSeq ORF: 1164
• Locus ID: 8811
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction
• Gene Summary: Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]