PTPN22 (NM_012411) Human Untagged Clone

CAT#: SC303978

PTPN22 (untagged)-Human protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PTPN22
• Synonyms: LYP; LYP1; LYP2; PEP; PTPN8; PTPN22.5; PTPN22.6
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_012411, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGACCAAAGAGAAATTCTGCAGAAGTTCCTGGATGAGGCCCAAAGCAAGAAAATTACTAAAGAGGAGT
  TTGCCAATGAATTTCTGAAGCTGAAAAGGCAATCTACCAAGTACAAGGCAGACAAAACCTATCCTACAAC
  TGTGGCTGAGAAGCCCAAGAATATCAAGAAAAACAGATATAAGGATATTTTGCCCTATGATTATAGCCGG
  GTAGAACTATCCCTGATAACCTCTGATGAGGATTCCAGCTACATCAATGCCAACTTCATTAAGGGAGTTT
  ATGGACCCAAGGCTTATATTGCCACCCAGGGTCCTTTATCTACAACCCTCCTGGACTTCTGGAGGATGAT
  TTGGGAATATAGTGTCCTTATCATTGTTATGGCATGCATGGAGTATGAAATGGGAAAGAAAAAGTGTGAG
  CGCTACTGGGCTGAGCCAGGAGAGATGCAGCTGGAATTTGGCCCTTTCTCTGTATCCTGTGAAGCTGAAA
  AAAGGAAATCTGATTATATAATCAGGACTCTAAAAGTTAAGTTCAATAGTGAAACTCGAACTATCTACCA
  GTTTCATTACAAGAATTGGCCAGACCATGATGTACCTTCATCTATAGACCCTATTCTTGAGCTCATCTGG
  GATGTACGTTGTTACCAAGAGGATGACAGTGTTCCCATATGCATTCACTGCAGTGCTGGCTGTGGAAGGA
  CTGGTGTTATTTGTGCTATTGATTATACATGGATGTTGCTAAAAGATGGGAGTCAAGCAAAGCATTGTAT
  TCCTGAGAAAAATCACACTCTCCAAGCAGACTCTTATTCTCCTAATTTACCAAAAAGTACCACAAAAGCA
  GCAAAAATGATGAACCAACAAAGGACAAAAATGGAAATCAAAGAATCTTCTTCCTTTGACTTTAGGACTT
  CTGAAATAAGTGCAAAAGAAGAGCTAGTTTTGCACCCTGCTAAATCAAGCACTTCTTTTGACTTTCTGGA
  GCTAAATTACAGTTTTGACAAAAATGCTGACACAACCATGAAATGGCAGACAAAGGCATTTCCAATAGTT
  GGGGAGCCTCTTCAGAAGCATCAAAGTTTGGATTTGGGCTCTCTTTTGTTTGAGGGATGTTCTAATTCTA
  AACCTGTAAATGCAGCAGGAAGATATTTTAATTCAAAGGTGCCAATAACACGGACCAAATCAACTCCTTT
  TGAATTGATACAGCAGAGAGAAACCAAGGAGGTGGACAGCAAGGAAAACTTTTCTTATTTGGAATCTCAA
  CCACATGATTCTTGTTTTGTAGAGATGCAGGCTCAAAAAGTAATGCATGTTTCTTCAGCAGAACTGAATT
  ATTCACTGCCATATGACTCTAAACACCAAATACGTAATGCCTCTAATGTAAAGCACCATGACTCTAGTGC
  TCTTGGTGTATATTCTTACATACCTTTAGTGGAAAATCCTTATTTTTCATCATGGCCTCCAAGTGGTACC
  AGTTCTAAGATGTCTCTTGATTTACCTGAGAAGCAAGATGGAACTGTTTTTCCTTCTTCTCTGTTGCCAA
  CATCCTCTACATCCCTCTTCTCTTATTACAATTCACATGATTCTTTATCACTGAATTCTCCAACCAATAT
  TTCCTCACTATTGAACCAGGAGTCAGCTGTACTAGCAACTGCTCCAAGGATAGATGATGAAATCCCCCCT
  CCACTTCCTGTACGGACACCTGAATCATTTATTGTGGTTGAGGAAGCTGGAGAATTCTCACCAAATGTTC
  CCAAATCCTTATCCTCAGCTGTGAAGGTAAAAATTGGAACATCACTGGAATGGGGTGGAACATCTGAACC
  AAAGAAATTTGATGACTCTGTGATACTTAGACCAAGCAAGAGTGTAAAACTCCGAAGTCCTAAATCAGAA
  CTACATCAAGATCGTTCTTCTCCCCCACCTCCTCTCCCAGAAAGAACTCTAGAGTCCTTCTTTCTTGCCG
  ATGAAGATTGTATGCAGGCCCAATCTATAGAAACATATTCTACTAGCTATCCTGACACCATGGAAAATTC
  AACATCTTCAAAACAGACACTGAAGACTCCTGGAAAAAGTTTCACAAGGAGTAAGAGTTTGAAAATTTTG
  CGAAACATGAAAAAGAGTATCTGTAATTCTTGCCCACCAAACAAGCCTGCAGAATCTGTTCAGTCAAATA
  ACTCCAGCTCATTTCTGAATTTTGGTTTTGCAAACCGTTTTTCAAAACCCAAAGGACCAAGGAATCCACC
  ACCAACTTGGAATATTTAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_012411
• ORF Size: 2259 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_012411.5, NP_036543.4
• RefSeq Size: 3513
• RefSeq ORF: 2259
• Locus ID: 26191
• Domains: Y_phosphatase, PTPc_motif
• Protein Families: Druggable Genome, Phosphatase
• Gene Summary: This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]
  Transcript Variant: This variant (2) lacks two alternate in-frame exons in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1. Sequence Note:.