IQSEC2 (NM_015075) Human Untagged Clone

CAT#: SC304220

IQSEC2 (untagged)-Human IQ motif and Sec7 domain 2 (IQSEC2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IQSEC2
• Synonyms: BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC304220 sequence for NM_015075 edited (data generated by NextGen Sequencing)
  
  
  ATGGAGCCCCCCGGGAGGAGCAGCAGGTCCACAGCGTCTCATACTCTACACCAGTATTGCTGTCCTACTC
  AGGTCCTTGACTCCATGAAGCTTACCCCCTCAGGCAGGCTGGCAGAGAGCAGTGTGGAGGGTGATGCCCC
  AGGCAGTGACCTGAGCACAGCGGTTGATAGTCCTGGGAGCCAACCCCCCTACCGGCTGAGCCAGCTGCCC
  CCCTCCAGCAGCCACATGGGGGGCCCCCCTGCTGGAGTGGGCCTTCCCTGGGCTCAGCGGGCACGCCTCC
  AGCCAGCCAGTGTCGCCCTGAGGAAGCAGGAGGAGGAGGAGATAAAGCGCTCCAAGGCCCTATCGGACAG
  CTATGAACTCTCCACAGACCTGCAGGACAAGAAGGTGGAAATGCTGGAGAGGAAGTATGGGGGCTCCTTC
  CTGAGCCGCAGGGCTGCCAGGACCATCCAGACAGCCTTCCGCCAGTACCGCATGAACAAGAACTTTGAGC
  GGCTACGCAGCTCAGCCTCAGAGAGCCGCATGTCCCGCCGCATCATCCTTTCCAACATGCGGATGCAGTT
  CTCCTTTGAGGAGTATGAGAAGGCACAGAACCCCGCGTACTTCGAGGGCAAGCCTGCCTCGCTGGACGAG
  GGTGCCATGGCTGGTGCCCGGAGCCACCGGCTTGAACGGGGGCTCCCATATGGAGGCTCCTGTGGTGGGG
  GCATCGATGGTGGTGGAAGCTCCGTCACCACATCTGGAGAGTTTTCTAATGACATCACAGAACTTGAGGA
  CTCCTTCTCCAAACAGGTAAAGTCTCTGGCTGAATCCATCGACGAAGCCCTGAACTGCCACCCGTCAGGG
  CCCATGTCTGAGGAGCCAGGGTCAGCCCAGCTGGAGAAGCGGGAGTCAAAGGAACAGCAAGAGGACAGCT
  CAGCCACATCCTTCAGTGATCTTCCCCTCTACCTGGATGACACAGTTCCCCAACAATCCCCTGAGCGACT
  GCCCAGCACAGAACCCCCACCCCAGGGCCGGCCCGAGTTCTGGGCGCCAGCCCCTCTCCCGCCAGTTCCT
  CCACCAGTGCCATCAGGAACCCGGGAAGACGGTAGCCGTGAGGAAGGCACTCGCAGGGGTCCCGGGTGCT
  TGGAGTGCCGGGATTTCCGGCTGCGGGCTGCCCACCTTCCCCTGCTTACCATTGAGCCTCCTAGTGACAG
  CTCCGTGGACCTGAGTGACCGCTCAGATCGCGGCTCTGTCCACCGCCAGCTGGTGTATGAGGCTGATGGC
  TGCAGCCCCCATGGGACCCTGAAGCACAAGGGGCCACCAGGCAGGGCCCCGATCCCACACCGCCACTACC
  CAGCCCCTGAAGGCCCAGCCCCAGCCCCACCAGGGCCCCTGCCACCAGCCCCCAACAGTGGCACTGGGCC
  CAGTGGTGTGGCTGGGGGTCGGAGGTTGGGGAAGTGCGAGGCAGCAGGCGAGAACTCTGATGGTGGAGAT
  AACGAGAGCCTTGAGAGCTCCAGCAATTCCAATGAGACCATCAACTGCAGCTCCGGCTCCTCTTCTCGGG
  ACAGTCTAAGGGAGCCTCCGGCTACCGGCCTGTGCAAGCAGACTTACCAGCGGGAGACAAGGCATAGCTG
  GGACTCGCCAGCTTTCAACAATGATGTGGTCCAGAGGCGGCACTACCGAATCGGCCTCAACCTCTTCAAC
  AAGAAGCCAGAGAAGGGTATCCAGTATCTGATCGAGCGGGGCTTCCTGTCAGACACACCGGTGGGAGTGG
  CTCACTTCATCCTGGAGCGGAAAGGCCTCAGCCGGCAGATGATAGGGGAATTCCTAGGGAACCGGCAGAA
  GCAGTTCAACAGAGACGTGTTGGACTGTGTGGTGGATGAGATGGACTTCTCCTCCATGGATCTGGATGAT
  GCGCTCCGGAAGTTCCAGTCCCATATCCGGGTTCAGGGTGAGGCCCAGAAAGTGGAGCGACTCATCGAAG
  CCTTCAGCCAGCGGTACTGTGTCTGTAACCCAGCCCTCGTGCGCCAGTTCCGGAACCCAGACACCATCTT
  CATCCTTGCTTTTGCCATCATCCTCCTCAATACCGACATGTACAGTCCCAGCGTCAAAGCTGAACGAAAG
  ATGAAACTAGATGACTTCATCAAGAACCTGAGAGGGGTTGACAATGGTGAAGACATCCCCCGAGACCTCC
  TGGTGGGCATCTACCAGCGCATCCAGGGGCGTGAACTGCGGACCAACGATGACCATGTGTCCCAGGTGCA
  GGCTGTGGAGCGCATGATTGTTGGAAAGAAACCAGTCCTGTCTCTCCCTCACCGTCGACTGGTTTGCTGC
  TGCCAGCTCTACGAGGTGCCAGATCCAAACCGCCCCCAGAGGCTAGGGTTGCATCAGCGGGAGGTCTTCC
  TCTTCAATGATCTCCTTGTGGTCACCAAAATTTTCCAGAAGAAGAAGATCTTGGTGACGTACAGTTTCCG
  TCAGTCTTTCCCCCTCGTGGAAATGCACATGCAGCTCTTCCAGAATTCATATTACCAGTTTGGGATCAAG
  TTGCTGTCTGCAGTACCTGGTGGGGAGCGAAAAGTCCTCATCATCTTCAATGCCCCCAGCCTCCAGGACC
  GGCTGCGCTTTACATCCGACCTGCGCGAGTCCATTGCGGAGGTGCAGGAGATGGAGAAATACCGTGTGGA
  GTCGGAGCTGGAGAAGCAGAAAGGTATGATGCGGCCTAACGCCTCACAGCCTGGAGGGGCCAAGGACTCA
  GTGAATGGGACGATGGCCCGCAGTAGCCTGGAGGACACTTACGGGGCAGGCGATGGGCTCAAACGGGGCG
  CACTCAGCAGTTCCCTGCGAGACCTCTCTGATGCAGGGGTCTGTTATTAG
  
  Clone variation with respect to NM_015075.1
  
• Restriction Sites: Please inquire
• ACCN: NM_015075
• ORF Size: 2850 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_015075.1, NP_055890.1
• RefSeq Size: 5248
• RefSeq ORF: 2850
• Locus ID: 23096
• Protein Pathways: Endocytosis
• Gene Summary: This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
  Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a novel ATG and an isoform (2) with distinct N- and C-termini, compared to isoform 1.