UBR1 (NM_174916) Human Untagged Clone

CAT#: SC309224

UBR1 (untagged)-Human ubiquitin protein ligase E3 component n-recognin 1 (UBR1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: UBR1
• Synonyms: JBS
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_174916, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCGGACGAGGAGGCTGGAGGTACTGAGAGGATGGAAATCAGCGCGGAGTTACCCCAGACCCCTCAGC
  GTCTGGCATCTTGGTGGGATCAGCAAGTTGATTTTTATACTGCTTTCTTGCATCATTTGGCACAATTGGT
  GCCAGAAATTTACTTTGCTGAAATGGACCCAGACTTGGAAAAGCAGGAGGAAAGTGTACAAATGTCAATA
  TTCACTCCACTGGAATGGTACTTATTTGGAGAAGATCCAGATATTTGCTTAGAGAAATTGAAGCACAGTG
  GAGCATTTCAGCTTTGTGGGAGGGTTTTCAAAAGTGGAGAGACAACCTATTCTTGCAGGGATTGTGCAAT
  TGATCCAACATGTGTACTCTGTATGGACTGCTTCCAGGACAGTGTTCATAAAAATCATCGTTACAAGATG
  CATACTTCTACTGGAGGAGGGTTCTGTGACTGTGGAGACACAGAGGCATGGAAAACTGGCCCTTTTTGTG
  TAAATCATGAACCTGGAAGAGCAGGTACTATAAAAGAGAATTCACGCTGTCCGTTGAATGAAGAGGTAAT
  TGTCCAAGCCAGGAAAATATTTCCTTCAGTGATAAAATATGTCGTAGAAATGACTATATGGGAAGAGGAA
  AAAGAACTGCCTCCTGAACTCCAGATAAGGGAGAAAAATGAAAGATACTATTGTGTCCTTTTCAATGATG
  AACACCATTCATATGACCACGTCATATACAGCCTACAAAGAGCTCTTGACTGTGAGCTCGCAGAGGCCCA
  GTTGCATACCACTGCCATTGACAAAGAGGGTCGTCGGGCTGTTAAAGCGGGAGCTTATGCTGCTTGCCAG
  GAAGCAAAGGAAGATATAAAGAGTCATTCAGAAAATGTCTCTCAACATCCACTTCATGTAGAAGTATTAC
  ACTCAGAGATTATGGCTCATCAGAAATTTGCTTTGCGTCTTGGTTCCTGGATGAACAAAATTATGAGCTA
  TTCAAGTGACTTTAGGCAGATCTTTTGCCAAGCATGCCTTAGAGAAGAACCTGACTCGGAGAATCCCTGT
  CTCATAAGCAGGTTAATGCTTTGGGATGCAAAGCTTTATAAAGGTGCCCGTAAGATCCTTCATGAATTGA
  TCTTCAGCAGTTTTTTTATGGAGATGGAATACAAAAAACTCTTTGCTATGGAATTTGTGAAGTATTATAA
  ACAACTGCAGAAAGAATATATCAGTGATGATCATGACAGAAGTATCTCTATAACTGCACTTTCAGTTCAG
  ATGTTTACTGTTCCTACTCTGGCTCGACATCTTATTGAAGAGCAGAATGTTATCTCTGTCATTACTGAAA
  CTCTGCTAGAAGTTTTACCTGAGTACTTGGACAGGAACAATAAATTCAACTTCCAGGGTTATAGCCAGGA
  CAAATTGGGAAGAGTATATGCAGTAATATGTGACCTAAAGTATATCCTGATCAGCAAACCCACAATATGG
  ACAGAAAGATTAAGAATGCAGTTCCTTGAAGGTTTTCGATCTTTTTTGAAGATTCTTACCTGTATGCAGG
  GAATGGAAGAAATCCGAAGACAGGTTGGGCAACACATTGAAGTGGATCCTGATTGGGAGGCTGCCATTGC
  TATACAGATGCAATTGAAGAATATTTTACTCATGTTCCAAGAGTGGTGTGCTTGTGATGAAGAACTCTTA
  CTTGTGGCTTATAAAGAATGTCACAAAGCTGTGATGAGGTGCAGTACCAGTTTCATATCTAGTAGCAAGA
  CAGTAGTACAATCGTGTGGACATAGTTTGGAAACAAAGTCCTACAGAGTATCTGAGGATCTTGTAAGCAT
  ACATCTGCCACTCTCTAGGACCCTTGCTGGTCTTCATGTACGTTTAAGCAGGCTGGGTGCTGTTTCAAGA
  CTGCATGAATTTGTGTCTTTTGAGGACTTTCAAGTAGAGGTACTAGTGGAATATCCTTTACGTTGTCTGG
  TGTTGGTTGCCCAGGTTGTTGCTGAGATGTGGCGAAGAAATGGACTGTCTCTTATTAGCCAGGTGTTTTA
  TTACCAAGATGTTAAGTGCAGAGAAGAAATGTATGATAAAGATATCATCATGCTTCAGATTGGTGCATCT
  TTAATGGATCCCAATAAGTTCTTGTTACTGGTACTTCAGAGGTATGAACTTGCCGAGGCTTTTAACAAGA
  CCATATCTACAAAAGACCAGGATTTGATTAAACAATATAATACACTAATAGAAGAAATGCTTCAGGTCCT
  CATCTATATTGTGGGTGAGCGTTATGTACCTGGAGTGGGAAATGTGACCAAAGAAGAGGTCACAATGAGA
  GAAATCATTCACTTGCTTTGCATTGAACCCATGCCACACAGTGCCATTGCCAAAAATTTACCTGAGAATG
  AAAATAATGAAACTGGCTTAGAGAATGTCATAAACAAAGTGGCCACATTTAAGAAACCAGGTGTATCAGG
  CCATGGAGTTTATGAACTAAAAGATGAATCACTGAAAGACTTCAATATGTACTTTTATCATTACTCCAAA
  ACCCAGCATAGCAAGGCTGAACATATGCAGAAGAAAAGGAGAAAACAAGAAAACAAAGATGAAGCATTGC
  CGCCACCACCACCTCCTGAATTCTGCCCTGCTTTCAGCAAAGTGATTAACCTTCTCAACTGTGATATCAT
  GATGTACATTCTCAGGACCGTATTTGAGCGGGCAATAGACACAGATTCTAACTTGTGGACCGAAGGGATG
  CTCCAAATGGCTTTTCATATTCTGGCATTGGGTTTACTAGAAGAGAAGCAACAGCTTCAAAAAGCTCCTG
  AAGAAGAAGTAACATTTGACTTTTATCATAAGGCTTCAAGATTGGGAAGTTCAGCCATGAATATACAAAT
  GCTTTTGGAAAAACTCAAAGGAATTCCCCAGTTAGAAGGCCAGAAGGACATGATAACGTGGATACTTCAG
  ATGTTTGACACAGTGAAGCGATTAAGAGAAAAATCTTGTTTAATTGTAGCAACCACATCAGGATCGGAAT
  CTATTAAGAATGATGAGATTACTCATGATAAAGAAAAAGCAGAACGAAAAAGAAAAGCTGAAGCTGCTAG
  GCTACATCGCCAGAAGATCATGGCTCAGATGTCTGCCTTACAGAAAAACTTCATTGAAACTCATAAACTC
  ATGTATGACAATACATCAGAAATGCCTGGGAAAGAAGATTCCATTATGGAGGAAGAGAGCACCCCAGCAG
  TCAGTGACTACTCTAGAATTGCTTTGGGTCCTAAACGGGGTCCATCTGTTACTGAAAAGGAGGTGCTGAC
  GTGCATCCTTTGCCAAGAAGAACAGGAGGTGAAAATAGAAAATAATGCCATGGTATTATCGGCCTGTGTC
  CAGAAATCTACTGCCTTAACCCAGCACAGGGGAAAACCCATAGAACTCTCAGGAGAAGCCCTAGACCCAC
  TTTTCATGGATCCAGACTTGGCATATGGAACTTATACAGGAAGCTGTGGTCATGTAATGCACGCAGTGTG
  CTGGCAGAAGTATTTTGAAGCTGTACAGCTGAGCTCTCAGCAGCGCATTCATGTTGACCTTTTTGACTTG
  GAAAGTGGAGAATATCTTTGCCCTCTTTGCAAATCTCTGTGCAATACTGTGATCCCCATTATTCCTTTGC
  AACCTCAAAAGATAAACAGTGAGAATGCAGATGCTCTTGCTCAACTTTTGACCCTGGCACGGTGGATACA
  GACTGTTCTGGCCAGAATATCAGGTTATAATATAAGACATGCTAAAGGAGAAAACCCAATTCCTATTTTC
  TTTAATCAAGGAATGGGAGATTCTACTTTGGAGTTCCATTCCATCCTGAGTTTTGGCGTTGAGTCTTCGA
  TTAAATATTCAAATAGCATCAAGGAAATGGTTATTCTCTTTGCCACAACAATTTATAGAATTGGATTGAA
  AGTGCCACCTGATGAAAGGGATCCTCGAGTCCCCATGCTGACCTGGAGCACCTGCGCTTTCACTATCCAG
  GCAATTGAAAATCTATTGGGAGATGAAGGAAAACCTCTGTTTGGAGCACTTCAAAATAGGCAGCATAATG
  GTCTGAAAGCATTAATGCAGTTTGCAGTTGCACAGAGGATTACCTGTCCTCAGGTCCTGATACAGAAACA
  TCTGGTTCGTCTTCTATCAGTTGTTCTTCCTAACATAAAATCAGAAGATACACCATGCCTTCTGTCTATA
  GATCTGTTTCATGTTTTGGTGGGTGCTGTGTTAGCATTCCCATCCTTGTATTGGGATGACCCTGTTGATC
  TGCAGCCTTCTTCAGTTAGTTCTTCCTATAACCACCTTTATCTCTTCCATTTGATCACCATGGCACACAT
  GCTTCAGATACTACTTACAGTAGACACAGGCCTACCCCTTGCTCAGGTTCAAGAAGACAGTGAAGAGGCT
  CATTCCGCATCTTCTTTCTTTGCAGAAATTTCTCAATATACAAGTGGCTCCATTGGGTGTGATATTCCTG
  GCTGGTATTTGTGGGTCTCACTGAAGAATGGCATCACCCCTTATCTTCGCTGTGCTGCATTGTTTTTCCA
  CTATTTACTTGGGGTAACTCCGCCTGAGGAACTGCATACCAATTCTGCAGAAGGAGAGTACAGTGCACTC
  TGTAGCTATCTATCTTTACCTACAAATTTGTTCCTGCTCTTCCAGGAATATTGGGATACTGTAAGGCCCT
  TGCTCCAGAGGTGGTGTGCAGATCCTGCCTTACTAAACTGTTTGAAGCAAAAAAACACCGTGGTCAGGTA
  CCCTAGAAAAAGAAATAGTTTGATAGAGCTTCCTGATGACTATAGCTGCCTCCTGAATCAAGCTTCTCAT
  TTCAGGTGCCCACGGTCTGCAGATGATGAGCGAAAGCATCCTGTCCTCTGCCTTTTCTGTGGGGCTATAC
  TATGTTCTCAGAACATTTGCTGCCAGGAAATTGTGAACGGGGAAGAGGTTGGAGCTTGCATTTTTCACGC
  ACTTCACTGTGGAGCCGGAGTCTGCATTTTCCTAAAAATCAGAGAATGCCGAGTGGTCCTGGTTGAAGGT
  AAAGCCAGAGGCTGTGCCTATCCAGCTCCTTACTTGGATGAATATGGAGAAACAGACCCTGGCCTGAAGA
  GGGGCAACCCCCTTCATTTATCTCGTGAGCGGTATCGGAAGCTCCATTTGGTCTGGCAACAACACTGCAT
  TATAGAAGAGATTGCTAGGAGCCAAGAGACTAATCAGATGTTATTTGGATTCAACTGGCAGTTACTGTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_174916
• ORF Size: 5250 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_174916.2, NP_777576.1
• RefSeq Size: 7758
• RefSeq ORF: 5250
• Locus ID: 197131
• Protein Families: Druggable Genome
• Gene Summary: The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]