CFHR5 (NM_030787) Human Untagged Clone

CAT#: SC314042

CFHR5 (untagged)-Human complement factor H-related 5 (CFHR5)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CFHR5
• Synonyms: CFHL5; CFHR5D; FHR-5; FHR5
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_030787, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGTTGCTCTTATTCAGTGTAATCCTAATCTCATGGGTATCCACTGTTGGGGGAGAAGGAACACTTTGTG
  ATTTTCCAAAAATACACCATGGATTTCTGTATGATGAAGAAGATTATAACCCTTTTTCCCAAGTTCCTAC
  AGGGGAAGTTTTCTATTACTCCTGTGAATATAATTTTGTGTCTCCTTCAAAATCCTTTTGGACTCGCATA
  ACATGCACAGAAGAAGGATGGTCACCAACACCGAAGTGTCTCAGAATGTGTTCCTTTCCTTTTGTGAAAA
  ATGGTCATTCTGAATCTTCAGGACTAATACATCTGGAAGGTGATACTGTACAAATTATTTGCAACACAGG
  ATACAGCCTTCAAAACAATGAGAAAAACATTTCGTGTGTAGAACGGGGCTGGTCCACTCCTCCCATATGC
  AGCTTCACTAAAGGAGAATGTCATGTTCCAATTTTAGAAGCCAATGTAGATGCTCAGCCAAAAAAAGAAA
  GCTACAAAGTTGGAGACGTGTTGAAATTCTCCTGCAGAAAAAATCTTATAAGAGTTGGATCAGACTCAGT
  TCAATGTTACCAATTTGGGTGGTCACCTAACTTTCCAACATGCAAAGGACAAGTACGATCATGTGGTCCA
  CCTCCTCAACTCTCCAATGGTGAAGTTAAGGAGATAAGAAAAGAGGAATATGGACACAATGAAGTAGTGG
  AATATGATTGCAATCCTAATTTTATAATAAACGGGCCTAAGAAAATACAATGTGTGGATGGAGAATGGAC
  AACTTTACCCACTTGTGTTGAACAAGTGAAAACATGTGGATACATACCTGAACTCGAGTACGGTTATGTT
  CAGCCGTCTGTCCCTCCCTATCAACATGGAGTTTCAGTCGAGGTGAATTGCAGAAATGAATATGCAATGA
  TTGGAAATAACATGATTACCTGTATTAATGGAATATGGACAGAGCTTCCTATGTGTGTTGCAACACACCA
  ACTTAAGAGGTGCAAAATAGCAGGAGTTAATATAAAAACATTACTCAAGCTATCTGGGAAAGAATTTAAT
  CATAATTCTAGAATACGTTACAGATGTTCAGACATCTTCAGATACAGGCACTCAGTCTGTATAAACGGGA
  AATGGAATCCTGAAGTAGACTGCACAGAAAAAAGGGAACAATTCTGCCCACCGCCACCTCAGATACCTAA
  TGCTCAGAATATGACAACCACAGTGAATTATCAGGATGGAGAAAAAGTAGCTGTTCTCTGTAAAGAAAAC
  TATCTACTTCCAGAAGCAAAAGAAATTGTATGTAAAGATGGACGATGGCAATCATTACCACGCTGTGTTG
  AGTCTACTGCATATTGTGGGCCCCCTCCATCTATTAACAATGGAGATACCACCTCATTCCCATTATCAGT
  ATATCCTCCAGGGTCAACAGTGACGTACCGTTGCCAGTCCTTCTATAAACTCCAGGGCTCTGTAACTGTA
  ACATGCAGAAATAAACAGTGGTCAGAACCACCAAGATGCCTAGATCCATGTGTGGTATCTGAAGAAAACA
  TGAACAAAAATAACATACAGTTAAAATGGAGAAACGATGGAAAACTCTATGCAAAAACAGGGGATGCTGT
  TGAATTCCAGTGTAAATTCCCACATAAAGCGATGATATCATCACCACCATTTCGAGCAATCTGTCAGGAA
  GGGAAATTTGAATATCCTATATGTGAATGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_030787
• ORF Size: 1710 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_030787.3, NP_110414.1
• RefSeq Size: 2829
• RefSeq ORF: 1710
• Locus ID: 81494
• Domains: CCP
• Protein Families: Secreted Protein, Transmembrane
• Gene Summary: This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010]