RIN2 (NM_018993) Human Untagged Clone

CAT#: SC314879

RIN2 (untagged)-Human Ras and Rab interactor 2 (RIN2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RIN2
• Synonyms: MACS; RASSF4
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_018993, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGACAGCTTGGACCATGGGCGCCCGCGGTCTGGACAAGCGAGGAAGTTTCTTTAAGCTCATTGACACAA
  TTGCCTCGGAGATCGGAGAACTGAAACAGGAGATGGTGCGGACAGATGTCAACCTGGAAAATGGCCTGGA
  ACCCGCTGAAACCCACAGCATGGTAAGACACAAGGATGGTGGCTATTCCGAGGAAGAGGACGTGAAGACC
  TGTGCCCGGGACTCAGGCTATGACAGCCTCTCCAACAGGCTCAGCATCTTGGACCGGCTCCTCCACACCC
  ACCCCATATGGCTGCAGCTGAGTCTGAGTGAGGAGGAGGCAGCAGAGGTCCTGCAGGCCCAGCCTCCGGG
  GATCTTCCTGGTTCATAAATCTACCAAGATGCAGAAGAAAGTCCTCTCCCTCCGCCTGCCCTGTGAATTT
  GGGGCCCCACTCAAGGAATTTGCCATAAAGGAAAGCACATACACCTTTTCCCTGGAAGGCTCAGGAATCA
  GTTTCGCAGATTTATTCCGGCTCATTGCTTTCTACTGCATCAGCAGGGATGTTCTACCATTTACCTTGAA
  GTTGCCTTATGCCATTTCAACAGCCAAGTCGGAGGCTCAGCTTGAAGAACTGGCCCAGATGGGACTAAAT
  TTCTGGAGCTCCCCAGCTGACAGCAAACCCCCGAACCTTCCACCTCCCCATAGGCCTCTTTCCTCCGACG
  GTGTCTGTCCTGCCTCCCTGCGTCAGCTCTGCCTTATAAATGGAGTGCATTCTATCAAAACCAGGACGCC
  TTCAGAGCTGGAGTGCAGCCAGACCAACGGGGCCCTGTGCTTTATTAATCCCCTTTTCTTGAAAGTGCAC
  AGCCAGGACCTCAGTGGAGGCCTGAAACGGCCGAGCACAAGGACTCCCAACGCGAATGGCACGGAGCGGA
  CTCGGTCCCCCCCACCCAGGCCCCCGCCACCCGCTATTAATAGTCTCCACACAAGCCCTCGGCTGGCCAG
  GACTGAAACCCAGACGAGCATGCCAGAAACAGTCAACCATAACAAACATGGGAACGTAGCTCTGCCTGGA
  ACGAAACCAACTCCCATCCCTCCACCCCGGCTGAAGAAGCAGGCTTCTTTTCTGGAAGCAGAGGGCGGTG
  CAAAGACCTTGAGCGGCGGCCGGCCGGGCGCAGGCCCGGAGCTGGAGCTGGGCACAGCTGGCAGCCCAGG
  TGGGGCCCCGCCTGAGGCCGCCCCGGGGGATTGCACAAGGGCCCCGCCGCCCAGCTCTGAATCACGGCCC
  CCGTGCCATGGAGGCCGGCAGCGGCTGAGCGACATGAGCATTTCTACTTCCTCCTCCGACTCGCTGGAGT
  TCGACCGGAGCATGCCTCTGTTTGGCTACGAGGCGGACACCAACAGCAGCCTGGAGGACTACGAGGGGGA
  AAGTGACCAAGAGACCATGGCGCCCCCCATCAAGTCCAAAAAGAAAAGGAGCAGCTCCTTCGTGCTGCCC
  AAGCTCGTCAAGTCCCAGCTGCAGAAGGTGAGCGGGGTGTTCAGCTCCTTCATGACCCCGGAGAAGCGGA
  TGGTCCGCAGGATCGCCGAGCTTTCCCGGGACAAATGCACCTACTTCGGGTGCTTAGTGCAGGACTACGT
  GAGCTTCCTGCAGGAGAACAAGGAGTGCCACGTGTCCAGCACCGACATGCTGCAGACCATCCGGCAGTTC
  ATGACCCAGGTCAAGAACTATTTGTCTCAGAGCTCGGAGCTGGACCCCCCCATCGAGTCGCTGATCCCTG
  AAGACCAAATAGATGTGGTGCTGGAAAAAGCCATGCACAAGTGCATCTTGAAGCCCCTCAAGGGGCACGT
  GGAGGCCATGCTGAAGGACTTTCACATGGCCGATGGCTCATGGAAGCAACTCAAGGAGAACCTGCAGCTT
  GTGCGGCAGAGGAATCCGCAGGAGCTGGGGGTCTTCGCCCCGACCCCTGATTTTGTGGATGTGGAGAAAA
  TCAAAGTCAAGTTCATGACCATGCAGAAGATGTATTCGCCGGAAAAGAAGGTCATGCTGCTGCTGCGGGT
  CTGCAAGCTCATTTACACGGTCATGGAGAACAACTCAGGGAGGATGTATGGCGCTGATGACTTCTTGCCA
  GTCCTGACCTATGTCATAGCCCAGTGTGACATGCTTGAATTGGACACTGAAATCGAGTACATGATGGAGC
  TCCTAGACCCATCGCTGTTACATGGAGAAGGAGGCTATTACTTGACAAGCGCATATGGAGCACTTTCTCT
  GATAAAGAATTTCCAAGAAGAACAAGCAGCGCGACTGCTCAGCTCAGAAACCAGAGACACCCTGAGGCAG
  TGGCACAAACGGAGAACCACCAACCGGACCATCCCCTCTGTGGACGACTTCCAGAATTACCTCCGAGTTG
  CATTTCAGGAGGTCAACAGTGGTTGCACAGGAAAGACCCTCCTTGTGAGACCTTACATCACCACTGAGGA
  TGTGTGTCAGATCTGCGCTGAGAAGTTCAAGGTGGGGGACCCTGAGGAGTACAGCCTCTTTCTCTTCGTT
  GACGAGACATGGCAGCAGCTGGCAGAGGACACTTACCCTCAAAAAATCAAGGCGGAGCTGCACAGCCGAC
  CACAGCCCCACATCTTCCACTTTGTCTACAAACGCATCAAGAACGATCCTTATGGCATCATTTTCCAGAA
  CGGGGAAGAAGACCTCACCACCTCCTAG
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_018993
• ORF Size: 2688 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_018993.3, NP_061866.1
• RefSeq Size: 4265
• RefSeq ORF: 2688
• Locus ID: 54453
• Domains: RA, VPS9
• Gene Summary: The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
  Transcript Variant: This variant (2) lacks a portion of the 5' UTR and 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.