DMP1 (NM_001079911) Human Untagged Clone

CAT#: SC315785

DMP1 (untagged)-Human dentin matrix acidic phosphoprotein 1 (DMP1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DMP1
• Synonyms: ARHP; ARHR; DMP-1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001079911, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGAAGATCAGCATCCTGCTCATGTTCCTTTGGGGATTATCCTGTGCTCTCCCAGTAACCAGGTATCAAA
  ATAATGAATCTGAGGATTCTGAAGAATGGAAGGGTCATTTGGCTCAGGCACCAACACCACCCTTGGCAAA
  TGAAGACCCCAGTGACAGCACTCAGTCAGAGGAGGGCCTGGGCTCTGATGATCATCAATACATTTATAGG
  CTAGCTGGTGGCTTCTCCAGGAGCACAGGAAAAGGAGGAGATGATAAAGATGACGATGAAGATGACAGTG
  GAGATGACACCTTTGGTGACGATGACAGTGGCCCAGGGCCCAAAGACAGACAAGAAGGAGGAAACTCCAG
  ACTGGGAAGTGATGAGGACTCTGATGACACCATACAAGCCAGTGAAGAGAGTGCCCCACAAGGGCAAGAC
  AGTGCCCAAGATACCACCAGTGAGAGCAGGGAACTTGACAATGAGGACCGGGTGGACAGCAAGCCTGAGG
  GAGGTGACTCCACTCAAGAGAGTGAGAGTGAAGAGCACTGGGTGGGAGGTGGCAGTGATGGGGAGAGCAG
  CCATGGAGACGGCTCCGAGTTGGACGATGAGGGAATGCAGAGTGATGACCCAGAGAGCATCAGGAGTGAA
  AGGGGAAACTCCAGAATGAACAGTGCAGGCATGAAATCAAAAGAATCTGGAGAAAACAGTGAGCAAGCAA
  ACACTCAAGATTCAGGTGGCAGCCAATTGCTGGAGCATCCCAGTAGGAAAATTTTTAGGAAGTCTCGCAT
  CTCAGAGGAAGATGACAGAAGCGAGCTTGATGACAACAACACAATGGAAGAAGTCAAGAGTGACTCTACA
  GAAAACAGCAACTCCAGAGACACTGGCCTCAGCCAACCCAGGAGAGACAGCAAGGGTGACTCTCAAGAAG
  ACAGCAAGGAGAATCTGTCCCAGGAAGAGAGCCAAAACGTAGATGGTCCCAGCAGTGAGTCCAGCCAAGA
  GGCCAACCTGTCATCTCAAGAGAACAGCAGTGAGTCTCAGGAAGAGGTGGTGAGTGAGTCCAGGGGAGAT
  AACCCCGACCCCACAACTAGTTATGTAGAAGACCAGGAAGACAGTGACTCCAGCGAGGAGGACAGCTCGC
  ACACACTCTCCCACTCAAAAAGTGAATCCAGAGAGGAGCAAGCAGACAGCGAATCCAGTGAGAGCCTCAA
  CTTCTCAGAGGAAAGCCCGGAGTCCCCTGAGGATGAGAACAGCTCCAGCCAGGAGGGCCTCCAGTCTCAC
  AGCAGCTCAGCAGAGAGTCAGAGCGAGGAAAGCCATTCTGAGGAAGACGACAGTGACTCTCAAGACAGCA
  GCAGATCCAAAGAAGATAGCAACTCCACGGAGAGCAAATCAAGCAGTGAGGAAGATGGCCAGTTGAAAAA
  CATTGAGATAGAGAGCCGGAAATTAACAGTTGATGCCTATCACAACAAACCCATTGGGGACCAAGATGAC
  AATGACTGCCAAGACGGCTATTAG
  
  
• Restriction Sites: Please inquire
• ACCN: NM_001079911
• ORF Size: 1494 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.

Reference Data

• RefSeq: NM_001079911.1, NP_001073380.1
• RefSeq Size: 2631
• RefSeq ORF: 1494
• Locus ID: 1758
• Protein Families: Secreted Protein
• Gene Summary: Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) lacks an internal in-frame exon, compared to variant 1, resulting in a protein (isoform 2) that is 16 aa shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments and data in PMID:15108359.