LILRB4 (NM_001081438) Human Untagged Clone

CAT#: SC315950

LILRB4 (untagged)-Human leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 (LILRB4), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LILRB4
• Synonyms: CD85K; HM18; ILT3; LILRB5; LIR-5; LIR5
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001081438, the custom clone sequence may differ by one or more nucleotides
  ATGATCCCCACCTTCACGGCTCTGCTCTGCCTCGGGCTGAGTCTGGGCCCCAGGACCCAC
  ATGCAGGCAGGGCCCCTCCCCAAACCCACCCTCTGGGCTGAGCCAGGCTCTGTGATCAGC
  TGGGGGAACTCTGTGACCATCTGGTGTCAGGGGACCCTGGAGGCTCGGGAGTACCGTCTG
  GATAAAGAGGAAAGCCCAGCACCCTGGGACAGACAGAACCCACTGGAGCCCAAGAACAAG
  GCCAGATTCTCCATCCCATCCATGACAGAGGACTATGCAGGGAGATACCGCTGTTACTAT
  CGCAGCCCTGTAGGCTGGTCACAGCCCAGTGACCCCCTGGAGCTGGTGATGACAGGAGCC
  TACAGTAAACCCACCCTTTCAGCCCTGCCGAGTCCTCTTGTGACCTCAGGAAAGAGCGTG
  ACCCTGCTGTGTCAGTCACGGAGCCCAATGGACACTTTCCTTCTGATCAAGGAGCGGGCA
  GCCCATCCCCTACTGCATCTGAGATCAGAGCACGGAGCTCAGCAGCACCAGGCTGAATTC
  CCCATGAGTCCTGTGACCTCAGTGCACGGGGGGACCTACAGGTGCTTCAGCTCACACGGC
  TTCTCCCACTACCTGCTGTCACACCCCAGTGACCCCCTGGAGCTCATAGTCTCAGGATCC
  TTGGAGGATCCCAGGCCCTCACCCACAAGGTCCGTCTCAACAGCTGCAGGCCCTGAGGAC
  CAGCCCCTCATGCCTACAGGGTCAGTCCCCCACAGTGGTCTGAGAAGGCACTGGGAGGTA
  CTGATCGGGGTCTTGGTGGTCTCCATCCTGCTTCTCTCCCTCCTCCTCTTCCTCCTCCTC
  CAACACTGGCGTCAGGGAAAACACAGGACATTGGCCCAGAGACAGGCTGATTTCCAACGT
  CCTCCAGGGGCTGCCGAGCCAGAGCCCAAGGACGGGGGCCTACAGAGGAGGTCCAGCCCA
  GCTGCTGACGTCCAGGGAGAAAACTTCTGTGCTGCCGTGAAGAACACACAGCCTGAGGAC
  GGGGTGGAAATGGACACTCGGAGCCCACACGATGAAGACCCCCAGGCAGTGACGTATGCC
  AAGGTGAAACACTCCAGACCTAGGAGAGAAATGGCCTCTCCTCCCTCCCCACTGTCTGGG
  GAATTCCTGGACACAAAGGACAGACAGGCAGAAGAGGACAGACAGATGGACACTGAGGCT
  GCTGCATCTGAAGCCCCCCAGGATGTGACCTACGCCCAGCTGCACAGCTTTACCCTCAGA
  CAGAAGGCAACTGAGCCTCCTCCATCCCAGGAAGGGGCCTCTCCAGCTGAGCCCAGTGTC
  TATGCCACTCTGGCCATCCAC
  
• Restriction Sites: Please inquire
• ACCN: NM_001081438
• ORF Size: 1344 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001081438.1, NP_001074907.1
• RefSeq Size: 2094
• RefSeq ORF: 1344
• Locus ID: 11006
• Protein Families: Transmembrane
• Gene Summary: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a protein (isoform 2) that is 1 aa shorter than isoform 1.