PION (GSAP) (NM_017439) Human Untagged Clone

CAT#: SC318332

PION (untagged)-Human pigeon homolog (Drosophila) (PION)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: GSAP
• Synonyms: PION
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_017439, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCTCTTCGCCTGGTCGCCGACTTCGACCTCGGGAAGGACGTGCTCCCGTGGTTGCGGGCGCAGCGGG
  CAGTGTCGGAGGCCAGCGGGGCCGGAAGCGGCGGCGCAGATGTTTTAGAAAACGATTATGAGAGCTTACA
  TGTATTAAATGTTGAAAGAAATGGAAATATTATTTATACCTATAAGGATGATAAGGGAAATGTCGTCTTT
  GGATTATATGATTGTCAAACCAGACAAAATGAGCTTCTATATACCTTTGAGAAAGACTTGCAAGTTTTCA
  GTTGCTCTGTCAACAGTGAAAGGACTTTGCTTGCTGCAAGTTTAGTTCAGTCTACTAAAGAAGGAAAAAG
  GAACGAACTTCAACCAGGATCAAAGTGCTTGACTTTGTTGGTTGAAATCCACCCTGTTAACAATGTGAAG
  GTTCTAAAGGCTGTGGATAGCTATATTTGGGTTCAGTTTCTCTACCCACATATTGAAAGTCATCCTCTTC
  CAGAGAACCATCTGTTACTGATTTCAGAAGAGAAATATATTGAACAATTTCGTATCCATGTCGCCCAAGA
  AGATGGAAATAGAGTGGTGATTAAAAATTCTGGCCATCTCCCAAGAGACAGAATAGCTGAGGATTTCGTT
  TGGGCTCAGTGGGATATGTCAGAACAGAGATTATATTACATTGACCTGAAGAAATCAAGGAGTATCTTAA
  AATGTATCCAGTTTTATGCTGATGAGAGCTATAACTTAATGTTTGAAGTACCCTTGGACATATCATTAAG
  CAACTCAGGATTTAAACTTGTCAACTTTGGATGTGATTATCATCAATACCGAGATAAATTTTCCAAACAC
  CTGACTCTGTGTGTTTTTACCAACCATACAGGAAGTTTGTGTGTATGTTACAGCCCGAAGTGTGCCTCTT
  GGGGACAAATCACATATTCAGTGTTTTACATTCATAAAGGACACAGCAAGACCTTCACCACTTCTCTTGA
  GAATGTTGGGTCACACATGACAAAGGGCATTACTTTTCTCAACCTTGACTATTATGTGGCTGTTTACTTA
  CCTGGTCATTTCTTCCACCTACTTAATGTTCAACATCCAGACCTGATCTGCCACAATCTCTTTCTGACAG
  GAAATAATGAAATGATTGATATGCTACCTCATTGCCCTTTACAGTCATTGTCAGGGTCCCTGGTATTGGA
  TTGTTGTTCTGGAAAGCTCTATAGAGCACTGCTCAGCCAGTCGTCTTTATTACAGCTTCTGCAGAACACT
  TGCTTAGACTGTGAGAAGATGGCTGCGTTGCACTGCGCGCTCTACTGCGGTCAAGGTGCGCAGTTCCTGG
  AAGCCCAGATTATTCAGTGGATTTCTGAGAATGTCTCTGCCTGCCATTCATTTGACCTCATTCAGGAATT
  TATAATTGCTTCTTCATACTGGAGTGTATATTCAGAGACAAGTAACATGGACAAACTATTGCCACATTCC
  TCAGTGCTCACTTGGAATACAGAAATTCCTGGAATAACTCTTGTGACAGAAGACATTGCATTGCCTCTTA
  TGAAGGTGCTCAGCTTTAAGGGCTACTGGGAAAAACTGAACTCCAACCTAGAATATGTTAAGTACGCCAA
  GCCACACTTCCACTATAACAACAGTGTGGTCAGGAGAGAGTGGCACAACCTGATCTCTGAAGAGAAAACA
  GGAAAAAGAAGGTCTGCGGCATACGTGAGGAATATTCTTGATAATGCAGTAAAGGTGATTTCTAACCTAG
  AAGCAAGAAATTTGGGGCCAAGATTAACACCCCTCCTGCAGGAGGAAGACAGCCACCAGCGGCTGCTCAT
  GGGGCTGATGGTGTCTGAGCTAAAAGACCATTTTTTGAGACACCTACAGGGTGTAGAAAAGAAGAAAATT
  GAACAGATGGTTCTGGACTACATTTCAAAACTGCTGGATCTCATTTGCCACATCGTAGAAACCAATTGGA
  GGAAACATAATCTTCATTCCTGGGTTCTCCACTTCAATAGTCGTGGCAGTGCTGCTGAATTTGCAGTTTT
  TCACATCATGACCAGGATTCTGGAAGCTACAAACAGTTTGTTTTTACCTCTGCCTCCTGGTTTTCATACT
  CTGCACACCATCCTCGGGGTCCAGTGTCTCCCTTTGCATAACCTGCTGCATTGCATTGACAGTGGAGTGT
  TGCTTCTCACTGAAACAGCTGTCATAAGGCTCATGAAAGATCTGGATAATACAGAGAAAAATGAAAAACT
  GAAATTCAGTATCATTGTGCGGCTTCCTCCGCTTATTGGGCAGAAGATTTGTAGACTTTGGGATCATCCT
  ATGAGTTCTAACATCATTTCGCGGAACCACGTGACGCGACTGCTTCAGAACTATAAGAAACAGCCTCGGA
  ATTCTATGATTAACAAGTCATCGTTCAGTGTAGAATTTCTGCCTCTGAACTACTTCATTGAAATTCTGAC
  AGATATAGAGTCCTCCAATCAAGCCCTGTATCCTTTTGAAGGACATGACAATGTGGATGCAGAATTTGTA
  GAGGAAGCAGCTCTGAAACACACCGCGATGCTTTTAGGCTTATGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_017439
• ORF Size: 2565 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_017439.3, NP_059135.2
• RefSeq Size: 3265
• RefSeq ORF: 2565
• Locus ID: 54103
• Protein Families: Druggable Genome
• Gene Summary: Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]). [supplied by OMIM, Nov 2010]