EMAP II (AIMP1) (NM_004757) Human Untagged Clone

CAT#: SC320792

AIMP1 (untagged)-Human aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: AIMP1
• Synonyms: EMAP2; EMAPII; HLD3; p43; SCYE1
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004757.2 GACCTACATGCTTCCTGCTGTGGCTGTCTCGGAACCCGTGGTCCTCCGCTTCATGATTTT
  CTGCCGTCTCTTGGCAAAAATGGCAAATAATGATGCTGTTCTGAAGAGACTGGAGCAGAA
  GGGTGCAGAGGCAGATCAAATCATTGAATATCTTAAGCAGCAAGTTTCTCTACTTAAGGA
  GAAAGCAATTTTGCAGGCAACTTTGAGGGAAGAGAAGAAACTTCGAGTTGAAAATGCTAA
  ACTGAAGAAAGAAATTGAAGAACTGAAACAAGAGCTAATTCAGGCAGAAATTCAAAATGG
  AGTGAAGCAAATACCATTTCCATCTGGTACTCCACTGCACGCTAATTCTATGGTTTCTGA
  AAATGTGATACAGTCTACAGCAGTAACAACCGTATCTTCTGGTACCAAAGAACAGATAAA
  AGGAGGAACAGGAGACGAAAAGAAAGCGAAAGAGAAAATTGAAAAGAAAGGAGAGAAGAA
  GGAGAAAAAACAGCAATCAATAGCTGGAAGTGCCGACTCTAAGCCAATAGATGTTTCCCG
  TCTGGATCTTCGAATTGGTTGCATCATAACTGCTAGAAAACACCCTGATGCAGATTCTTT
  GTATGTGGAAGAAGTAGATGTCGGAGAAATAGCCCCAAGGACAGTTGTCAGTGGCCTGGT
  GAATCATGTTCCTCTTGAACAGATGCAAAATCGGATGGTGATTTTACTTTGTAACCTGAA
  ACCTGCAAAGATGAGGGGAGTATTATCTCAAGCAATGGTCATGTGTGCTAGTTCACCAGA
  GAAAATTGAAATCTTGGCTCCTCCAAATGGGTCTGTTCCTGGAGACAGAATTACTTTTGA
  TGCTTTCCCAGGAGAGCCTGACAAGGAGCTGAATCCTAAGAAGAAGATTTGGGAGCAGAT
  CCAGCCTGATCTTCACACTAATGATGAGTGTGTGGCTACATACAAAGGAGTTCCCTTTGA
  GGTGAAAGGGAAGGGAGTATGTAGGGCTCAAACCATGAGCAACAGTGGAATCAAATAAAA
  TGCTTCCACTACCAAAAGACATTAGAGAAAACCTTAAAAGTAATAAAGAGAAATATATTT
  GTCACTTATACCTAAAATATGAGTGGCTCATTTTTGCATTACTCTCTTCTAGACTTGACT
  AGTCATTTACTTGGTATATATTGTTTTCATTGATTGGGGAAACACTAGATTTTTACCTCG
  GTTTTTGATCATTTATAATGGAGAGAGGAAGTTGCCTATGTTTTGTAATAATTTATTTTT
  TAGCAGGAATATTGATTAGCAGCTTTTTTTTCTTTATACACATAGATAACTAACTAGATT
  AATGTTTAGTTTCTTATTTGTAGGCACAGGATGCATGAAATTTCAAGCTCTGGGATTTTT
  TGTATATTGTGTATCTGTATCAAAAATATCCTCTCCTTTTCAAAAATGACAGGTTGGAAA
  ATGTTTGTCAGACTTATTAACTGGTCATATTATAATAATACTGATAATGACCAACTGCTC
  ATTCTGAAAGCCAAACATAAAAGCTAGGAGAAGTGGCATCTGAACATTTTTGCTTTGCTG
  CCAGAGTAACCCTGACTAATAATACAATAACAGCAATTTTTTTAAAAAACTGAGATTTCC
  TACTGGCTTGAAGTTTTTCTATTTAGCAAAATAATTAGTAATAAGTTTTGACTAGGTCTA
  AAGAATGAACACATTGTAAACAGTTGCCACAGTAGTTTCTAATAAATTGATCATAAAAGC
  AAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004757.2 unedited
  TCGATTGTATACGACTCCTATAGGGCGGCCGGAAATTCGGCACGAGGGACCTACATGCTT
  CCTGCTGTGGCTGTCTCGGAACCCGTGGTCCTCCGCTTCATGATTTTCTGCCGTCTCTTG
  GCAAAAATGGCAAATAATGATGCTGTTCTGAAGAGACTGGAGCAGAAGGGTGCAGAGGCA
  GATCAAATCATTGAATATCTTAAGCAGCAAGTTTCTCTACTTAAGGAGAAAGCAATTTTG
  CAGGCAACTTTGAGGGAAGAGAAGAAACTTCGAGTTGAAAATGCTAAACTGAAGAAAGAA
  ATTGAAGAACTGAAACAAGAGCTAATTCAGGCAGTAATTCAAAATGGAGTGAAGCAAATA
  CCATTTCCATCTGGTACTCCACTGCACGCTAATTCTATGGTTTCTGAAAATGTGATACAG
  TCTACAGCAGTAACAACCGTATCTTCTGGTACCAAAGAACAGATAAAAGGAGGAACAGGA
  GACGAAAAGAAAGCGAAAGAGAAAATTGAAAAGAAAGGAGAGAAGAAGGAGAAAAAACAG
  CAATCAATAGCTGGAAGTGCCGACTCTAAGCCAATAGATGTTTCCCGTCTGGATCTTCGA
  ATTGGTTGCATCATAACTGCTAGAAAACACCCTGATGCAGATTCTTTGTATGTGGAAGAA
  GTAGATGTCGGAGAAATAGCCCCAAGGACAGTTGTCAGTGGCCCTGGTGAATCATGTTCC
  TCTTGAACAGATGCAAAATCGGATGGTGATTTTACTTTGTAACCTGAAACCTGCAAAGAT
  GAGGGAGTATTATCTCAAGCAATGGTCATGTGTGCTAGTTCACCAGAGAAAATTGAAATC
  TTGCTCTCAAATGGTCTTGTTCTGGGAGACAGATACTTTTGATGCTTCCAGAGAGCTGAC
  AAGCAGCTGATCCTAGAGAAGATTGGGGCAGAATTCAGCCTGAATTCTTCCCACCTAATG
  GAATAGAATGTGTGTGTGGTA
• Restriction Sites: Please inquire
• ACCN: NM_004757
• ORF Size: 939 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_004757.2, NP_004748.2
• RefSeq Size: 1764
• RefSeq ORF: 939
• Locus ID: 9255
• Domains: tRNA_bind
• Protein Families: Druggable Genome
• Gene Summary: The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Both variants 1 and 2 encode the same isoform.