alpha Defensin 1 (DEFA1B) (NM_001042500) Human Untagged Clone

CAT#: SC321787

DEFA1B (untagged)-Human defensin, alpha 1B (DEFA1B)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DEFA1B
• Synonyms: HNP-1; HP-1; HP1
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001042500.1 GACCTGGGACAGAGGACTGCTGTCTGCCCTCTCTGGTCACCCTGCCTAGCTAGAGGATCT
  GTGACCCCAGCCATGAGGACCCTCGCCATCCTTGCTGCCATTCTCCTGGTGGCCCTGCAG
  GCCCAGGCTGAGCCACTCCAGGCAAGAGCTGATGAGGTTGCTGCAGCCCCGGAGCAGATT
  GCAGCGGACATCCCAGAAGTGGTTGTTTCCCTTGCATGGGACGAAAGCTTGGCTCCAAAG
  CATCCAGGCTCAAGGAAAAACATGGACTGCTATTGCAGAATACCAGCGTGCATTGCAGGA
  GAACGTCGCTATGGAACCTGCATCTACCAGGGAAGACTCTGGGCATTCTGCTGCTGAGCT
  TGCAGAAAAAGAAAAATGAGCTCAAAATTTGCTTTGAGAGCTACAGGGAATTGCTATTAC
  TCCTGTACCTTCTGCTCAATTTCCTTTCCTCATCTCAAATAAATGCCTTGTTACAAGAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001042500.1 unedited
  GGCCTTTGTTATACGACTCCTATAGGGCGGCCGGCGTATCGCGGCGCGCCGGTACCGGTC
  CGGAATTCCCGGGATGACCTGGGACAGAGGACTGCTGTCTGCCCTCTCTGGTCACCCTGC
  CTAGCTAGAGGATCTGTGACCCCAGCCATGAGGACCCTCGCCATCCTTGCTGCCATTCTC
  CTGGTGGCCCTGCAGGCCCAGGCTGAGCCACTCCAGGCAAGAGCTGATGAGGTTGCTGCA
  GCCCCGGAGCAGATTGCAGCGGACATCCCAGAAGTGGTTGTTTCCCTTGCATGGGACGAA
  AGCTTGGCTCCAAAGCATCCAGGCTCAAGGAAAAACATGGACTGCTATTGCAGAATACCA
  GCGTGCATTGCAGGAGAACGTCGCTATGGAACCTGCATCTACCAGGGAAGACTCTGGGCA
  TTCTGCTGCTGAGCTTGCAGAAAAAGAAAAATGAGCTCAAAATTTGCTTTGAGAGCTACA
  GGGAATTGCTATTACTCCTGTACCTTCTGCTCAATTTCCTTTCCTCATCTCAAATAAATG
  CCTTGTTACAAGAAAAAACAAAAAAAAAAAAAAAAAAAAAAAAAAAAGGGCGGCCGCACT
  CGAGGTTTAAACGGCCGGCCGCGGTCATAGCTGTTTCCTGAACAGATCCCGGGTGGCATC
  CCTGTGACCCCTCCCCAGTGCCTCTCCTGGCCCTGGAAGTTGCCACCTCCAGTGCCCACC
  AGCCTTGTCCTAATAAAATTAAGTTGCATCATTTTGTCTGACTAGTGTCTCCTTAATTTA
  TGGTTGAGGGGTGGTATAAGAGAACAGGGCCAAGTTTGGAAACACACTTAGCCTGCGGGT
  CTATGGGAACAGCTGATGCATGGCCAATCTGGCTCACTGCATTCCGCCTCCTGGTTCAAG
  CGATTTCTGCTAGCCTCCGATTGTGATCAGCATGCATGAACCAGGCTA
• Restriction Sites: Please inquire
• ACCN: NM_001042500
• ORF Size: 285 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001042500.1, NP_001035965.1
• RefSeq Size: 498
• RefSeq ORF: 285
• Locus ID: 728358
• Protein Families: Druggable Genome
• Gene Summary: Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
  Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at a downstream start site compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.