IL18BP (NM_173042) Human Untagged Clone

CAT#: SC324219

IL18BP (untagged)-Human interleukin 18 binding protein (IL18BP), transcript variant A

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IL18BP
• Synonyms: IL18BPa
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_173042.2 CACGCAGCTAGACACAGCTAACTTGAGTCTTGGAGCTCCTAGAGGGAAGCTTCTGGAAAG
  GAAGGCTCTTCAGGACCTCTTAGGAGCCAGTGTGAAGGTGAAGGAGGAAGCAGATGCCTG
  TTCATATGGAAACAAAGACCTGGCTGTGAAGAGGGGAGGCGGACACCAAAGTCCTGACAC
  TTGGGCGGGACAGAATTGATCTAGAAGAGGACGTTGTCACAGATAAAGAGCCAGGCTCAC
  CAGCTCCTGACGCATGCATCATGACCATGAGACACAACTGGACACCAGACCTCAGCCCTT
  TGTGGGTCCTGCTCCTGTGTGCCCACGTCGTCACTCTCCTGGTCAGAGCCACACCTGTCT
  CGCAGACCACCACAGCTGCCACTGCCTCAGTTAGAAGCACAAAGGACCCCTGCCCCTCCC
  AGCCCCCAGTGTTCCCAGCAGCTAAGCAGTGTCCAGCATTGGAAGTGACCTGGCCAGAGG
  TGGAAGTGCCACTGAATGGAACGCTGAGCTTATCCTGTGTGGCCTGCAGCCGCTTCCCCA
  ACTTCAGCATCCTCTACTGGCTGGGCAATGGTTCCTTCATTGAGCACCTCCCAGGCCGAC
  TGTGGGAGGGGAGCACCAGCCGGGAACGTGGGAGCACAGGTACGCAGCTGTGCAAGGCCT
  TGGTGCTGGAGCAGCTGACCCCTGCCCTGCACAGCACCAACTTCTCCTGTGTGCTCGTGG
  ACCCTGAACAGGTTGTCCAGCGTCACGTCGTCCTGGCCCAGCTCTGGGCTGGGCTGAGGG
  CAACCTTGCCCCCCACCCAAGAAGCCCTGCCCTCCAGCCACAGCAGTCCACAGCAGCAGG
  GTTAAGACTCAGCACAGGGCCAGCAGCAGCACAACCTTGACCAGAGCTTGGGTCCTACCT
  GTCTACCTGGAGTGAACAGTCCCTGACTGCCTGTAGGCTGCGTGGATGCGCAACACACCC
  CCTCCTTCTCTGCTTTGGGTCCCTTCTCTCACCAAATTCAAACTCCATTCCCACCTACCT
  AGAAAATCACAGCCTCCTTATAATGCCTCCTCCTCCTGCCATTCTCTCTCCACCTATCCA
  TTAGCCTTCCTAACGTCCTACTCCTCACACTGCTCTACTGCTCAGAAACCACCAAGACTG
  TTGATGCCTTAGCCTTGCACTCCAGGGCCCTACCTGCATTTCCCACATGACTTTCTGGAA
  GCCTCCCAACTATTCTTGCTTTTCCCAGACAGCTCCCACTCCCATGTCTCTGCTCATTTA
  GTCCCGTCTTCCTCACCGCCCCAGCAGGGGAACGCTCAAGCCTGGTTGAAATGCTGCCTC
  TTCAGTGAAGTCATCCTCTTTCAGCTCTGGCCGCATTCTGCAGACTTCCTATCTTCGTGC
  TGTATGTTTTTTTTTTTCCCCCTTCACTCTAATGGACTGTTCCAGGGAAGGGATGGGGGC
  AGCAGCTGCTTCGGATCCACACTGTATCTGTGTCATCCCCACATGGGTCCTCATAAAGGA
  TTATTCAATGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_173042.2 unedited
  GGCTTTCGCTGTATACGACCTCCCTCTAGGGCGGCCGGCGACTCGCGGCGCGCCGGTACC
  GGTCCGGAATTCCCGGGATCACGCAGCTAGACACAGCTAACTTGAGTCTTGGAGCTCCTA
  GAGGGAAGCTTCTGGAAAGGAAGGCTCTTCAGGACCTCTTAGGAGCCAGTGTGAAGGTGA
  AGGAGGAAGCAGATGCCTGTTCATATGGAAACAAAGACCTGGCTGTGAAGAGGGGAGGCG
  GACACCAAAGTCCTGACACTTGGGCGGGACAGAATTGATCTAGAAGAGGACGTTGTCACA
  GATAAAGAGCCAGGCTCACCAGCTCCTGACGCATGCATCATGACCATGAGACACAACTGG
  ACACCAGACCTCAGCCCTTTGTGGGTCCTGCTCCTGTGTGCCCACGTCGTCACTCTCCTG
  GTCAGAGCCACACCTGTCTCGCAGACCACCACAGCTGCCACTGCCTCAGTTAGAAGCACA
  AAGGACCCCTGCCCCTCCCAGCCCCCAGTGTTCCCAGCAGCTAAGCAGTGTCCAGCATTG
  GAAGTGACCTGGCCAGAGGTGGAAGTGCCACTGAATGGAACGCTGAGCTTATCCTGTGTG
  GCCTGCAGCCGCTTCCCCAACTTCAGCATCCTCTACTGGCTGGGCAATGGTTCCTTCATT
  GAGCACCTCCCAGGCCGACTGTGGGAGGGGAGCACCAGCCGGGAACGTGGGAGCACAGGT
  ACGCAGCTGTGCAAGGCCTTGGTGCTGGAGCAGCTGACCCCTGCCCTGCACAGCACCAAC
  TTCTCCTGTGTGCTCGTGACCCTGAACAGTTGTCCAGCGTCACGTCGTCTGCCAGCTCTG
  GGCTGGGCTGAGGCAACCTTGCCCCACCCAGAAGCCATGCTTTCAGCCACAGCAGTCCCA
  GCAGCAGTAAGACTCCAGCCAAGGCCGACGGCAGCAAACTGACCAAGCCTTGGTCCCTAA
  CTGTCTAACTTGGAATGTGACCG
• Restriction Sites: ECoRI-NOT
• ACCN: NM_173042
• ORF Size: 585 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_173042.2, NP_766630.2
• RefSeq Size: 2189
• RefSeq ORF: 585
• Locus ID: 10068
• Protein Families: Druggable Genome, Secreted Protein
• Gene Summary: The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
  Transcript Variant: This variant (A) encodes the predominant isoform (a, also known as IL-18BPa), which shows the highest affinity for binding IL-18 (PMID:10655506). Variants A, E, F and G encode the same isoform.