SH3BP2 (NM_001145855) Human Untagged Clone

CAT#: SC326596

SH3BP2 (untagged)-Human SH3-domain binding protein 2 (SH3BP2), transcript variant 4, mRNA

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SH3BP2
• Synonyms: 3BP-2; 3BP2; CRBM; CRPM; RES4-23
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001145855, the custom clone sequence may differ by one or more nucleotides
  ATGGCCTCCCTGGGCCCCAGGACACCGGCCCCGAGCAGGTCACGAGGACGGAGGGCCATG
  TGTTGGGTCAGCACCATCAGCTTCATGGCGGCTGAAGAGATGCATTGGCCTGTCCCTATG
  AAGGCCATTGGTGCCCAGAACCTGCTAACCATGCCTGGGGGCGTGGCCAAGGCTGGCTAC
  CTGCACAAGAAGGGCGGTACCCAGCTGCAGCTGCTGAAATGGCCCCTGCGCTTTGTCATC
  ATCCACAAACGCTGCGTCTACTACTTCAAGAGTAGCACCTCTGCCTCCCCGCAGGGCGCC
  TTCTCCCTGAGTGGCTATAACCGGGTGATGCGGGCGGCTGAGGAGACCACGTCCAACAAC
  GTTTTCCCCTTCAAGATCATCCATATCAGCAAGAAGCACCGCACGTGGTTCTTCTCGGCC
  TCCTCCGAGGAGGAGCGCAAGAGCTGGATGGCCTTGCTGCGCAGGGAGATTGGCCACTTC
  CACGAAAAGAAAGACCTGCCCTTGGACACCAGCGACTCCAGCTCGGACACAGACAGCTTC
  TACGGCGCAGTTGAGCGGCCTGTGGATATCAGCCTTTCCCCGTACCCCACGGACAATGAA
  GACTATGAGCACGACGATGAGGATGACTCCTACCTGGAGCCTGACTCCCCGGAGCCCGGA
  AGGCTTGAGGATGCCCTGATGCACCCACCGGCTTACCCACCACCCCCAGTGCCCACGCCC
  AGGAAGCCAGCCTTCTCTGACATGCCCCGGGCCCACTCCTTTACCTCCAAGGGCCCCGGT
  CCCCTACTGCCACCCCCGCCCCCTAAGCACGGCCTCCCAGATGTTGGCCTGGCTGCTGAG
  GACTCCAAGAGGGACCCACTGTGCCCGAGGCGGGCTGAGCCTTGCCCCAGGGTACCTGCT
  ACCCCCCGAAGGATGAGCGATCCCCCTCTGAGCACCATGCCCACCGCACCCGGCCTCCGG
  AAACCCCCTTGCTTCCGGGAGAGTGCCAGCCCCAGCCCGGAGCCCTGGACCCCTGGCCAC
  GGGGCCTGCTCCACTTCCAGTGCTGCCATCATGGCCACTGCCACCTCCAGAAACTGTGAC
  AAACTCAAGTCCTTCCACCTGTCCCCCCGAGGACCACCCACATCTGAGCCCCCACCTGTG
  CCAGCCAACAAGCCCAAGTTCCTGAAGATAGCTGAAGAGGACCCCCCAAGGGAGGCAGCC
  ATGCCCGGACTCTTTGTGCCCCCCGTGGCTCCCCGGCCTCCTGCGCTGAAGCTGCCAGTG
  CCTGAGGCCATGGCGCGGCCCGCAGTCCTGCCCAGGCCAGAGAAGCCGCAGCTCCCGCAC
  CTCCAGCGATCACCCCCCGATGGGCAGAGTTTCAGGAGCTTCTCCTTTGAAAAGCCCCGG
  CAACCCTCACAGGCTGACACTGGCGGGGACGACTCGGACGAGGACTATGAGAAGGTGCCA
  CTGCCCAACTCGGTCTTCGTCAACACCACGGAGTCCTGCGAAGTGGAAAGGTTGTTCAAG
  GCTACAAGCCCCCGGGGAGAGCCCCAGGATGGACTCTACTGCATCCGGAACTCCTCTACC
  AAGTCGGGGAAGGTCCTGGTTGTGTGGGACGAAACCTCTAACAAAGTGAGGAACTATCGC
  ATTTTTGAGAAGGACTCTAAGTTCTACCTGGAGGGCGAGGTCCTGTTTGTGAGTGTGGGC
  AGCATGGTGGAGCACTACCACACCCACGTGCTGCCCAGCCACCAGAGCCTGCTGCTGCGG
  CACCCCTACGGCTACACTGGGCCTAGG
  
• Restriction Sites: Please inquire
• ACCN: NM_001145855
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001145855.1, NP_001139327.1
• RefSeq Size: 9211 bp
• RefSeq ORF: 1770 bp
• Locus ID: 6452
• Cytogenetics: 4p16.3
• Protein Families: Druggable Genome
• Protein Pathways: Natural killer cell mediated cytotoxicity
• Gene Summary: 'The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]'
  Transcript Variant: This variant (4) represents use of an alternative promoter and 5' UTR and uses an alternate translation start site, compared to variant 3. The resulting isoform (c) has a shorter and distinct N-terminus, compared to isoform b. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.